Preclinical Cushing's syndrome: Report of four cases and analysis of steroid contents in adenomas

Masaaki Morioka, Yozo Ohashi, Fumito Komatsu, Koji Sawada, Shin Ebara, Teruhisa Ohashi, Katsuyoshi Kondo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We report 4 cases of preclinical Cushing's syndrome (PCS) that were discovered incidentally by computed tomography (CT) as adrenal incidentalomas. Routine endocrine examinations revealed a suppressed plasma ACTH level. A final diagnosis was made by means of precise endocrine assessments and adrenal scintigraphy with radiolabelled iodocholesterol. Although endocrine data varied, the positive accumulation of radioisotope in the adrenal tumor, with nonvisualization of the contralateral side, was observed in all cases. Endocrine studies and analyses of steroid contents in tumors by HPLC suggested that subtypes or heterogenous forms of this disease entity may exist. One type shows small tumors with relatively elevated cortisol production, and a disturbed diurnal rhythm and suppression of plasma cortisol with dexamethasone (DXM). The other type showed large tumors with weak-to-average cortisol production, and the diurnal rhythm of cortisol was preserved.

Original languageEnglish
Pages (from-to)117-123
Number of pages7
JournalHormone Research
Volume46
Issue number3
Publication statusPublished - 1996

Fingerprint

Cushing Syndrome
Adenoma
Hydrocortisone
Steroids
Circadian Rhythm
Neoplasms
Glandular and Epithelial Neoplasms
Radioisotopes
Radionuclide Imaging
Adrenocorticotropic Hormone
Dexamethasone
High Pressure Liquid Chromatography
Tomography

Keywords

  • CRH test
  • Dexamethasone suppression test
  • HPLC
  • Steroid contents in adenoma

ASJC Scopus subject areas

  • Endocrinology

Cite this

Morioka, M., Ohashi, Y., Komatsu, F., Sawada, K., Ebara, S., Ohashi, T., & Kondo, K. (1996). Preclinical Cushing's syndrome: Report of four cases and analysis of steroid contents in adenomas. Hormone Research, 46(3), 117-123.

Preclinical Cushing's syndrome : Report of four cases and analysis of steroid contents in adenomas. / Morioka, Masaaki; Ohashi, Yozo; Komatsu, Fumito; Sawada, Koji; Ebara, Shin; Ohashi, Teruhisa; Kondo, Katsuyoshi.

In: Hormone Research, Vol. 46, No. 3, 1996, p. 117-123.

Research output: Contribution to journalArticle

Morioka, M, Ohashi, Y, Komatsu, F, Sawada, K, Ebara, S, Ohashi, T & Kondo, K 1996, 'Preclinical Cushing's syndrome: Report of four cases and analysis of steroid contents in adenomas', Hormone Research, vol. 46, no. 3, pp. 117-123.
Morioka M, Ohashi Y, Komatsu F, Sawada K, Ebara S, Ohashi T et al. Preclinical Cushing's syndrome: Report of four cases and analysis of steroid contents in adenomas. Hormone Research. 1996;46(3):117-123.
Morioka, Masaaki ; Ohashi, Yozo ; Komatsu, Fumito ; Sawada, Koji ; Ebara, Shin ; Ohashi, Teruhisa ; Kondo, Katsuyoshi. / Preclinical Cushing's syndrome : Report of four cases and analysis of steroid contents in adenomas. In: Hormone Research. 1996 ; Vol. 46, No. 3. pp. 117-123.
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