Practical synthesis of glaziovianin A, a cytotoxic isoflavone, and its O7-propargyl analogue

Ichiro Hayakawa, Shuya Shioda, Akiyuki Ikedo, Hideo Kigoshi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Glaziovianin A and its O7-propargyl analogue are potent cytotoxic isoflavones. We found that the O7-propargyl analogue completely arrested cell-cycle progression. We have achieved the large-scale synthesis of glaziovianin A and its O7-propargyl analogue for further in vivo experimentation.

Original languageEnglish
Pages (from-to)544-549
Number of pages6
JournalBulletin of the Chemical Society of Japan
Volume87
Issue number4
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Chemistry(all)

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