Practical synthesis of dirhodium(II) tetrakis[N-phthaloyl-(S)- tertleucinate]

Hideyuki Tsutsui, Takumi Abe, Seiichi Nakamura, Masahiro Anada, Shunichi Hashimoto

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

An efficient and reliable procedure for the preparation of dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate], Rh2(S-PTTL)4, a universally effective catalyst for a range of enantioselective carbene transformations, is described. The N-phthaloylation of (S)-tert-leucine by the method of Bose with essentially no racemization is a key to this process.

Original languageEnglish
Pages (from-to)1366-1368
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume53
Issue number10
DOIs
Publication statusPublished - Oct 2005
Externally publishedYes

Keywords

  • Chiral catalyst
  • Dirhodium(II) carboxylate
  • N-phthaloylation
  • tert-leucine

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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