Practical resolution of 3-phenyl-2H-azirine-2-methanol at very low temperature by using lipase immobilized on porous ceramic and optimized acylating agent

Takashi Sakai, Akiko Matsuda, Toshinobu Korenaga, Tadashi Ema

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Abstract

A synthetically useful primary alcohol, 3-phenyl-2H-azirine-2-methanol, was resolved efficiently by a reaction at -40 °C with a lipase immobilized on the porous ceramic (Toyonite) and vinyl butanoate in ether (E value of 130 and TTN/h value of 7800).

Original languageEnglish
Pages (from-to)1819-1821
Number of pages3
JournalBulletin of the Chemical Society of Japan
Volume76
Issue number9
DOIs
Publication statusPublished - 2003

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ASJC Scopus subject areas

  • Chemistry(all)

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