Practical resolution of 3-phenyl-2H-azirine-2-methanol at very low temperature by using lipase immobilized on porous ceramic and optimized acylating agent

Takashi Sakai, Akiko Matsuda, Toshinobu Korenaga, Tadashi Ema

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A synthetically useful primary alcohol, 3-phenyl-2H-azirine-2-methanol, was resolved efficiently by a reaction at -40 °C with a lipase immobilized on the porous ceramic (Toyonite) and vinyl butanoate in ether (E value of 130 and TTN/h value of 7800).

Original languageEnglish
Pages (from-to)1819-1821
Number of pages3
JournalBulletin of the Chemical Society of Japan
Volume76
Issue number9
DOIs
Publication statusPublished - 2003

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Lipase
Ether
Methanol
Alcohols
Temperature
Toyonite
vinyl butyrate

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Practical resolution of 3-phenyl-2H-azirine-2-methanol at very low temperature by using lipase immobilized on porous ceramic and optimized acylating agent. / Sakai, Takashi; Matsuda, Akiko; Korenaga, Toshinobu; Ema, Tadashi.

In: Bulletin of the Chemical Society of Japan, Vol. 76, No. 9, 2003, p. 1819-1821.

Research output: Contribution to journalArticle

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