Practical Oppenauer (OPP) oxidation of alcohols with a modified aluminum catalyst

Takashi Ooi, Hidehito Otsuka, Tomoya Miura, Hayato Ichikawa, Keiji Maruoka

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

(Matrix presented) Modified aluminum catalyst 2 was found to be highly effective for Oppenauer (OPP) oxidation of alcohols under mild conditions. For example, oxidation of carveol in toluene with t-BuCHO (1.2 equiv) as a hydride acceptor in the presence of 2 (1 mol %) proceeded smoothly at 21°C to give carvone in 94% yield after 1 h. A practical aspect of this system was highlighted by the facile OPP oxidation of terpenoids and steroids with 1.2-3.0 equiv of acetone and 2 (3-5 mol %).

Original languageEnglish
Pages (from-to)2669-2672
Number of pages4
JournalOrganic Letters
Volume4
Issue number16
DOIs
Publication statusPublished - Aug 8 2002
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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