We describe the (triphenylphosphine (PPh3)-assisted methoxylation of acyl fluorides with cyclopentyl methyl ether (CPME) accelerated by tetrabutylammonium difluorotriphenysilicate (TBAT) via regiospecific C–OMe bond cleavage. Easily available CPME is utilized not only as the solvent, but a methoxylating agent in this transformation. The present method is featured by C–O and C–F bond cleavage under metal-free conditions, good functional-group tolerance, and wide substrate scope. Mechanistic studies revealed that the radical process was not involved.
- Acyl fluorides
- Carbon-oxygen bond cleavage
- Cyclopentyl methyl ether (CPME)
- Tetrabutylammonium difluorotriphenysilicate (TBAT)
ASJC Scopus subject areas
- Physical and Theoretical Chemistry