Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis

Kumiko Horiuchi, Sumiko Shiota, Teruo Kuroda, Tsutomu Hatano, Takashi Yoshida, Tomofusa Tsuchiya

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

We found that a crude extract from Salvia officinalis (sage) reduced the minimum inhibitory concentrations (MICs) of aminoglycosides in vancomycin-resistant enterococci (VRE). We isolated the effective compound from the extract and identified it as carnosol, one of diterpenoids. Carnosol showed a weak antimicrobial activity, and greatly reduced the MICs of various aminoglycosides (potentiated the antimicrobial activity of aminoglycosides) and some other types of antimicrobial agents in VRE. Carnosic acid, a related compound, showed the similar activity. The effect of carnosol and carnosic acid with gentamicin was synergistic.

Original languageEnglish
Pages (from-to)287-290
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume30
Issue number2
DOIs
Publication statusPublished - Feb 2007

Fingerprint

Salvia officinalis
Aminoglycosides
Microbial Sensitivity Tests
Diterpenes
Anti-Infective Agents
Gentamicins
Complex Mixtures
carnosol
salvin
Vancomycin-Resistant Enterococci

Keywords

  • Aminoglycoside
  • Carnosic acid
  • Carnosol
  • Vancomycin-resistant enterococci (VRE)

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis. / Horiuchi, Kumiko; Shiota, Sumiko; Kuroda, Teruo; Hatano, Tsutomu; Yoshida, Takashi; Tsuchiya, Tomofusa.

In: Biological and Pharmaceutical Bulletin, Vol. 30, No. 2, 02.2007, p. 287-290.

Research output: Contribution to journalArticle

Horiuchi, Kumiko ; Shiota, Sumiko ; Kuroda, Teruo ; Hatano, Tsutomu ; Yoshida, Takashi ; Tsuchiya, Tomofusa. / Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis. In: Biological and Pharmaceutical Bulletin. 2007 ; Vol. 30, No. 2. pp. 287-290.
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