Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis

Kumiko Horiuchi, Sumiko Shiota, Teruo Kuroda, Tsutomu Hatano, Takashi Yoshida, Tomofusa Tsuchiya

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)


We found that a crude extract from Salvia officinalis (sage) reduced the minimum inhibitory concentrations (MICs) of aminoglycosides in vancomycin-resistant enterococci (VRE). We isolated the effective compound from the extract and identified it as carnosol, one of diterpenoids. Carnosol showed a weak antimicrobial activity, and greatly reduced the MICs of various aminoglycosides (potentiated the antimicrobial activity of aminoglycosides) and some other types of antimicrobial agents in VRE. Carnosic acid, a related compound, showed the similar activity. The effect of carnosol and carnosic acid with gentamicin was synergistic.

Original languageEnglish
Pages (from-to)287-290
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Issue number2
Publication statusPublished - Feb 2007


  • Aminoglycoside
  • Carnosic acid
  • Carnosol
  • Vancomycin-resistant enterococci (VRE)

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science


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