Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis

Kumiko Horiuchi; Sumiko Shiota; Teruo Kuroda; Tsutomu Hatano; Takashi Yoshida; Tomofusa Tsuchiya

doi:10.1248/bpb.30.287

Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis

Kumiko Horiuchi, Sumiko Shiota, Teruo Kuroda, Tsutomu Hatano, Takashi Yoshida, Tomofusa Tsuchiya

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

We found that a crude extract from Salvia officinalis (sage) reduced the minimum inhibitory concentrations (MICs) of aminoglycosides in vancomycin-resistant enterococci (VRE). We isolated the effective compound from the extract and identified it as carnosol, one of diterpenoids. Carnosol showed a weak antimicrobial activity, and greatly reduced the MICs of various aminoglycosides (potentiated the antimicrobial activity of aminoglycosides) and some other types of antimicrobial agents in VRE. Carnosic acid, a related compound, showed the similar activity. The effect of carnosol and carnosic acid with gentamicin was synergistic.

Original language	English
Pages (from-to)	287-290
Number of pages	4
Journal	Biological and Pharmaceutical Bulletin
Volume	30
Issue number	2
DOIs	https://doi.org/10.1248/bpb.30.287
Publication status	Published - Feb 2007

Keywords

Aminoglycoside
Carnosic acid
Carnosol
Vancomycin-resistant enterococci (VRE)

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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abstract = "We found that a crude extract from Salvia officinalis (sage) reduced the minimum inhibitory concentrations (MICs) of aminoglycosides in vancomycin-resistant enterococci (VRE). We isolated the effective compound from the extract and identified it as carnosol, one of diterpenoids. Carnosol showed a weak antimicrobial activity, and greatly reduced the MICs of various aminoglycosides (potentiated the antimicrobial activity of aminoglycosides) and some other types of antimicrobial agents in VRE. Carnosic acid, a related compound, showed the similar activity. The effect of carnosol and carnosic acid with gentamicin was synergistic.",

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AU - Horiuchi, Kumiko

AU - Shiota, Sumiko

AU - Kuroda, Teruo

AU - Hatano, Tsutomu

AU - Yoshida, Takashi

AU - Tsuchiya, Tomofusa

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Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis

Abstract

Keywords

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