Potential treatment strategies for enhancing neuroplasticity and regeneration after ischemic stroke

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Strokes are a major cause of death and result in a drastic reduction in quality of life. Novel therapeutic strategies for patients suffering from stroke are thus required. Two possible strategies can be proposed for treating ischemic stroke: enhancing neuroplasticity, allowing the surviving neuronal cells to compensate for stroke-related impairment through brain reorganization, sprouting and rewiring of neuronal cells, or regeneration of neuronal cells, including enhancement of intrinsic neurogenesis and stem cell transplantation therapy with neural stem cells, embryonic stem cells or induced pluripotent stem cells. Endogenous neurogenesis or transplanted neural stem cells, embryonic stem cells or induced pluripotent stem cell-derived cells are able to not only supply newborn neurons integrated into a damaged neuronal network, but also produce growth factors into the recovering brains. These secretory factors enhance sprouting and angiogenesis and may be important in neuroplasticity and recovery in the poststroke brain.

Original languageEnglish
Pages (from-to)279-285
Number of pages7
JournalFuture Neurology
Volume7
Issue number3
DOIs
Publication statusPublished - May 2012

Fingerprint

Neuronal Plasticity
Regeneration
Stroke
Induced Pluripotent Stem Cells
Neural Stem Cells
Neurogenesis
Embryonic Stem Cells
Brain
Stem Cell Transplantation
Therapeutics
Cell- and Tissue-Based Therapy
Cause of Death
Intercellular Signaling Peptides and Proteins
Quality of Life
Newborn Infant
Neurons

Keywords

  • cell transplantation
  • iPS cells
  • neuroplasticity
  • rewiring
  • sprouting

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Potential treatment strategies for enhancing neuroplasticity and regeneration after ischemic stroke. / Yamashita, Toru; Abe, Koji.

In: Future Neurology, Vol. 7, No. 3, 05.2012, p. 279-285.

Research output: Contribution to journalArticle

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