Potential of synthetic endoperoxides against Trichomonas vaginalis in vitro

Min Young Seo, Jae Sook Ryu, Akira Sato, Yuji Kurosaki, Kyung Soo Chang, Hye-Sook Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Metronidazole is well known for medicine against Trichomonas vaginalis infection, but it has side effects though it is effective, and especially because reports of metronidazole-tolerant species are increasing, the development of new medicine is being required. Here, we noticed the killing effects of endoperoxide compounds, N-89 and N-251 as new antimalarial drug candidates, on T. vaginalis and searched the possibility of development of new medicine. We added each of metronidazole, artemisinin, and two of new endoperoxides (N-89 and N-251) to metronidazole-resistant and -sensitive species and compared its anti-trichomonal efficacy. For metronidazole, IC50 value, 50% of killing concentration for T. vaginalis, was very low for metronidazole-sensitive isolates (11.7 to 22.8 μM), but was high for metronidazole-resistant ones (182.9 to 730.4 μM). The IC50 values of N-89 and N-251 were 41.0 to 60.0 μM, and 82.0 to 300.0 μM for metronidazole-sensitive and -resistant isolates, respectively. In conclusion, we found the endoperoxides, N-89 and N-251, have anti-trichomonal effect against metronidazole-resistant T. vaginalis as well as metronidazole-sensitive ones. These results indicate that the anti-trichomonal effects for our endoperoxides are equivalent or better in metronidazole-resistant T. vaginalis in comparison to metronidazole.

Original languageEnglish
Pages (from-to)619-621
Number of pages3
JournalParasitology International
Volume66
Issue number5
DOIs
Publication statusPublished - Oct 1 2017

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Trichomonas vaginalis
Metronidazole
Medicine
Inhibitory Concentration 50
In Vitro Techniques
Trichomonas Infections
Antimalarials

Keywords

  • 1,2,6,7-tetraoxaspiro[7.11]nonadecane (N-89)
  • 6-(1,2,6,7-Tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251)
  • Anti-trichomonal activity
  • Endoperoxides
  • Metronidazole-resistant isolate
  • Trichomonas vaginalis

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Potential of synthetic endoperoxides against Trichomonas vaginalis in vitro. / Seo, Min Young; Ryu, Jae Sook; Sato, Akira; Kurosaki, Yuji; Chang, Kyung Soo; Kim, Hye-Sook.

In: Parasitology International, Vol. 66, No. 5, 01.10.2017, p. 619-621.

Research output: Contribution to journalArticle

Seo, Min Young ; Ryu, Jae Sook ; Sato, Akira ; Kurosaki, Yuji ; Chang, Kyung Soo ; Kim, Hye-Sook. / Potential of synthetic endoperoxides against Trichomonas vaginalis in vitro. In: Parasitology International. 2017 ; Vol. 66, No. 5. pp. 619-621.
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AB - Metronidazole is well known for medicine against Trichomonas vaginalis infection, but it has side effects though it is effective, and especially because reports of metronidazole-tolerant species are increasing, the development of new medicine is being required. Here, we noticed the killing effects of endoperoxide compounds, N-89 and N-251 as new antimalarial drug candidates, on T. vaginalis and searched the possibility of development of new medicine. We added each of metronidazole, artemisinin, and two of new endoperoxides (N-89 and N-251) to metronidazole-resistant and -sensitive species and compared its anti-trichomonal efficacy. For metronidazole, IC50 value, 50% of killing concentration for T. vaginalis, was very low for metronidazole-sensitive isolates (11.7 to 22.8 μM), but was high for metronidazole-resistant ones (182.9 to 730.4 μM). The IC50 values of N-89 and N-251 were 41.0 to 60.0 μM, and 82.0 to 300.0 μM for metronidazole-sensitive and -resistant isolates, respectively. In conclusion, we found the endoperoxides, N-89 and N-251, have anti-trichomonal effect against metronidazole-resistant T. vaginalis as well as metronidazole-sensitive ones. These results indicate that the anti-trichomonal effects for our endoperoxides are equivalent or better in metronidazole-resistant T. vaginalis in comparison to metronidazole.

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