Potential interaction of brain natriuretic peptide with hyperadiponectinemia in preeclampsia

Hisashi Masuyama, Etsuko Nobumoto, Seiji Inoue, Yuji Hiramatsu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Adiponectin was reported recently to have roles in the pathophysiology of preeclampsia. Moreover, elevation of adiponectin and brain natriuretic peptide (BNP) has been observed in preeclampsia. We examined the possible links between adiponectin and BNP in the pathophysiology of preeclampsia. We performed a cross-sectional study in 56 preeclampsia patients and 56 controls matched for gestational age and body mass index. The BNP, leptin, and adiponectin levels were measured by ELISA, and their mRNA expressions were evaluated in omental adipose tissue by real-time PCR. The effects of BNP on adiponectin and leptin mRNA expression and secretion were investigated in primary cultures of adipocytes from obese and normalweight women. The BNP, adiponectin, and leptin levels were significantly higher in preeclampsia patients compared with controls. The adiponectin level was increased significantly in normal-weight preeclampsia patients compared with overweight preeclampsia patients. Adiponectin mRNA expression was increased significantly in adipose tissues of preeclampsia patients compared with controls and was also increased significantly in normal-weight preeclampsia patients compared with overweight preeclampsia patients, whereas leptin was not. BNP and adiponectin showed significant positive correlations in both normal-weight and overweight preeclampsia patients. BNP had a significantly weaker effect on adiponectin in overweight compared with normal-weight preeclampsia patients. Moreover, BNP had a weaker effect on adiponectin production in adipocytes from overweight women compared with adipocytes from normal-weight women using primary culture of human adipocytes. These data suggested that BNP may play a role in hyperadiponectinemia of preeclampsia patients. The weaker effect of BNP on adiponectin production may participate in the pathophysiology of overweight preeclampsia patients.

Original languageEnglish
Pages (from-to)687-693
Number of pages7
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume302
Issue number6
DOIs
Publication statusPublished - Mar 2012

Fingerprint

Brain Natriuretic Peptide
Pre-Eclampsia
Adiponectin
Leptin
Adipocytes
Weights and Measures
Messenger RNA
Adipose Tissue
Gestational Age
Real-Time Polymerase Chain Reaction
Body Mass Index

Keywords

  • Adipocyte
  • Adiponectin
  • Obesity
  • Pregnancy

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Endocrinology, Diabetes and Metabolism

Cite this

Potential interaction of brain natriuretic peptide with hyperadiponectinemia in preeclampsia. / Masuyama, Hisashi; Nobumoto, Etsuko; Inoue, Seiji; Hiramatsu, Yuji.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 302, No. 6, 03.2012, p. 687-693.

Research output: Contribution to journalArticle

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