Potent novel nonsteroidal androgen antagonists with a phthalimide skeleton

Hiroyuki Miyachi, Akihiko Azuma, Takuya Kitamoto, Kozue Hayashi, Shigeaki Kato, Masafumi Koga, Bunzo Sato, Yuichi Hashimoto

Research output: Contribution to journalArticle

49 Citations (Scopus)


Anti-androgenic activity of various phthalimide analogs was evaluated based on inhibition of androgen-induced activation of nuclear androgen receptor (CAT assay) and on growth inhibition of the androgen-dependent clonal cell line SC-3. Some compounds showed very potent androgen-antagonistic activity.

Original languageEnglish
Pages (from-to)1483-1488
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Issue number11
Publication statusPublished - Jun 3 1997
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Miyachi, H., Azuma, A., Kitamoto, T., Hayashi, K., Kato, S., Koga, M., Sato, B., & Hashimoto, Y. (1997). Potent novel nonsteroidal androgen antagonists with a phthalimide skeleton. Bioorganic and Medicinal Chemistry Letters, 7(11), 1483-1488. https://doi.org/10.1016/S0960-894X(97)00249-7