Potent novel nonsteroidal androgen antagonists with a phthalimide skeleton

Hiroyuki Miyachi, Akihiko Azuma, Takuya Kitamoto, Kozue Hayashi, Shigeaki Kato, Masafumi Koga, Bunzo Sato, Yuichi Hashimoto

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Anti-androgenic activity of various phthalimide analogs was evaluated based on inhibition of androgen-induced activation of nuclear androgen receptor (CAT assay) and on growth inhibition of the androgen-dependent clonal cell line SC-3. Some compounds showed very potent androgen-antagonistic activity.

Original languageEnglish
Pages (from-to)1483-1488
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number11
DOIs
Publication statusPublished - Jun 3 1997
Externally publishedYes

Fingerprint

Androgen Antagonists
Skeleton
Androgens
Androgen Receptors
Cytoplasmic and Nuclear Receptors
Assays
Chemical activation
Cells
Cell Line
Growth
phthalimide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Miyachi, H., Azuma, A., Kitamoto, T., Hayashi, K., Kato, S., Koga, M., ... Hashimoto, Y. (1997). Potent novel nonsteroidal androgen antagonists with a phthalimide skeleton. Bioorganic and Medicinal Chemistry Letters, 7(11), 1483-1488. https://doi.org/10.1016/S0960-894X(97)00249-7

Potent novel nonsteroidal androgen antagonists with a phthalimide skeleton. / Miyachi, Hiroyuki; Azuma, Akihiko; Kitamoto, Takuya; Hayashi, Kozue; Kato, Shigeaki; Koga, Masafumi; Sato, Bunzo; Hashimoto, Yuichi.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 7, No. 11, 03.06.1997, p. 1483-1488.

Research output: Contribution to journalArticle

Miyachi, H, Azuma, A, Kitamoto, T, Hayashi, K, Kato, S, Koga, M, Sato, B & Hashimoto, Y 1997, 'Potent novel nonsteroidal androgen antagonists with a phthalimide skeleton', Bioorganic and Medicinal Chemistry Letters, vol. 7, no. 11, pp. 1483-1488. https://doi.org/10.1016/S0960-894X(97)00249-7
Miyachi, Hiroyuki ; Azuma, Akihiko ; Kitamoto, Takuya ; Hayashi, Kozue ; Kato, Shigeaki ; Koga, Masafumi ; Sato, Bunzo ; Hashimoto, Yuichi. / Potent novel nonsteroidal androgen antagonists with a phthalimide skeleton. In: Bioorganic and Medicinal Chemistry Letters. 1997 ; Vol. 7, No. 11. pp. 1483-1488.
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