Potent in vivo antimalarial activity of 3,15-di-O-acetylbruceolide against Plasmodium berghei infection in mice

Hye Sook Kim; Yasuharu Shibata; Naoko Ko; Naomi Ikemoto; Yuki Ishizuka; Nobutoshi Murakami; Masanori Sugimoto; Motomasa Kobayashi; Yusuke Wataya

doi:10.1016/S1383-5769(99)00023-9

Potent in vivo antimalarial activity of 3,15-di-O-acetylbruceolide against Plasmodium berghei infection in mice

Hye Sook Kim, Yasuharu Shibata, Naoko Ko, Naomi Ikemoto, Yuki Ishizuka, Nobutoshi Murakami, Masanori Sugimoto, Motomasa Kobayashi, Yusuke Wataya

Research output: Contribution to journal › Article

14 Citations (Scopus)

Abstract

The antimalarial activity of the O-acylated bruceolide derivative, 3,15-di-O-acetylbruceolide, was evaluated against Plasmodium berghei in vivo. The concentration of 3,15-di-O-acetylbruceolide required for 50% suppression (ED₅₀) of P. berghei in mice was 0.46±0.06 mg/kg/day, whereas bruceolide was only half as effective as 3,15-di-O-acetylbruceolide. Two antimalarial drugs used clinically, chloroquine and artemisinin, demonstrated only low activity corresponding to 1/4 and 1/12 of the ED₅₀ value of 3,15-di-O-acetylbruceolide, respectively. These results may be helpful in the design of better chemotherapeutic bruceolides against falciparum malaria. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	271-274
Number of pages	4
Journal	Parasitology International
Volume	48
Issue number	3
DOIs	https://doi.org/10.1016/S1383-5769(99)00023-9
Publication status	Published - Jan 1 2000

Keywords

3,15-di-O-acetylbruceolide
Antimalarial agent
Brucea javanica
P. berghei
P. falciparum

ASJC Scopus subject areas

Parasitology
Infectious Diseases

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10.1016/S1383-5769(99)00023-9

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Kim, H. S., Shibata, Y., Ko, N., Ikemoto, N., Ishizuka, Y., Murakami, N., Sugimoto, M., Kobayashi, M., & Wataya, Y. (2000). Potent in vivo antimalarial activity of 3,15-di-O-acetylbruceolide against Plasmodium berghei infection in mice. Parasitology International, 48(3), 271-274. https://doi.org/10.1016/S1383-5769(99)00023-9

Potent in vivo antimalarial activity of 3,15-di-O-acetylbruceolide against Plasmodium berghei infection in mice. / Kim, Hye Sook; Shibata, Yasuharu; Ko, Naoko; Ikemoto, Naomi; Ishizuka, Yuki; Murakami, Nobutoshi; Sugimoto, Masanori; Kobayashi, Motomasa; Wataya, Yusuke.

In: Parasitology International, Vol. 48, No. 3, 01.01.2000, p. 271-274.

Research output: Contribution to journal › Article

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