Potent in vivo antimalarial activity of 3,15-di-O-acetylbruceolide against Plasmodium berghei infection in mice

Hye Sook Kim, Yasuharu Shibata, Naoko Ko, Naomi Ikemoto, Yuki Ishizuka, Nobutoshi Murakami, Masanori Sugimoto, Motomasa Kobayashi, Yusuke Wataya

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The antimalarial activity of the O-acylated bruceolide derivative, 3,15-di-O-acetylbruceolide, was evaluated against Plasmodium berghei in vivo. The concentration of 3,15-di-O-acetylbruceolide required for 50% suppression (ED50) of P. berghei in mice was 0.46±0.06 mg/kg/day, whereas bruceolide was only half as effective as 3,15-di-O-acetylbruceolide. Two antimalarial drugs used clinically, chloroquine and artemisinin, demonstrated only low activity corresponding to 1/4 and 1/12 of the ED50 value of 3,15-di-O-acetylbruceolide, respectively. These results may be helpful in the design of better chemotherapeutic bruceolides against falciparum malaria. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)271-274
Number of pages4
JournalParasitology International
Volume48
Issue number3
DOIs
Publication statusPublished - Jan 1 2000

Keywords

  • 3,15-di-O-acetylbruceolide
  • Antimalarial agent
  • Brucea javanica
  • P. berghei
  • P. falciparum

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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    Kim, H. S., Shibata, Y., Ko, N., Ikemoto, N., Ishizuka, Y., Murakami, N., Sugimoto, M., Kobayashi, M., & Wataya, Y. (2000). Potent in vivo antimalarial activity of 3,15-di-O-acetylbruceolide against Plasmodium berghei infection in mice. Parasitology International, 48(3), 271-274. https://doi.org/10.1016/S1383-5769(99)00023-9