Potent in vivo antimalarial activity of 3,15-di-O-acetylbruceolide against Plasmodium berghei infection in mice

Hye Sook Kim; Yasuharu Shibata; Naoko Ko; Naomi Ikemoto; Yuki Ishizuka; Nobutoshi Murakami; Masanori Sugimoto; Motomasa Kobayashi; Yusuke Wataya

doi:10.1016/S1383-5769(99)00023-9

Potent in vivo antimalarial activity of 3,15-di-O-acetylbruceolide against Plasmodium berghei infection in mice

Hye Sook Kim, Yasuharu Shibata, Naoko Ko, Naomi Ikemoto, Yuki Ishizuka, Nobutoshi Murakami, Masanori Sugimoto, Motomasa Kobayashi, Yusuke Wataya

Research output: Contribution to journal › Article

14 Citations (Scopus)

Abstract

The antimalarial activity of the O-acylated bruceolide derivative, 3,15-di-O-acetylbruceolide, was evaluated against Plasmodium berghei in vivo. The concentration of 3,15-di-O-acetylbruceolide required for 50% suppression (ED₅₀) of P. berghei in mice was 0.46±0.06 mg/kg/day, whereas bruceolide was only half as effective as 3,15-di-O-acetylbruceolide. Two antimalarial drugs used clinically, chloroquine and artemisinin, demonstrated only low activity corresponding to 1/4 and 1/12 of the ED₅₀ value of 3,15-di-O-acetylbruceolide, respectively. These results may be helpful in the design of better chemotherapeutic bruceolides against falciparum malaria. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	271-274
Number of pages	4
Journal	Parasitology International
Volume	48
Issue number	3
DOIs	https://doi.org/10.1016/S1383-5769(99)00023-9
Publication status	Published - Jan 1 2000

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Keywords

3,15-di-O-acetylbruceolide
Antimalarial agent
Brucea javanica
P. berghei
P. falciparum

ASJC Scopus subject areas

Parasitology
Infectious Diseases

Cite this

Kim, H. S., Shibata, Y., Ko, N., Ikemoto, N., Ishizuka, Y., Murakami, N., Sugimoto, M., Kobayashi, M., & Wataya, Y. (2000). Potent in vivo antimalarial activity of 3,15-di-O-acetylbruceolide against Plasmodium berghei infection in mice. Parasitology International, 48(3), 271-274. https://doi.org/10.1016/S1383-5769(99)00023-9

Potent in vivo antimalarial activity of 3,15-di-O-acetylbruceolide against Plasmodium berghei infection in mice. / Kim, Hye Sook; Shibata, Yasuharu; Ko, Naoko; Ikemoto, Naomi; Ishizuka, Yuki; Murakami, Nobutoshi; Sugimoto, Masanori; Kobayashi, Motomasa; Wataya, Yusuke.

In: Parasitology International, Vol. 48, No. 3, 01.01.2000, p. 271-274.

Research output: Contribution to journal › Article

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10.1016/S1383-5769(99)00023-9