Abstract
The antimalarial activity of the O-acylated bruceolide derivative, 3,15-di-O-acetylbruceolide, was evaluated against Plasmodium berghei in vivo. The concentration of 3,15-di-O-acetylbruceolide required for 50% suppression (ED50) of P. berghei in mice was 0.46±0.06 mg/kg/day, whereas bruceolide was only half as effective as 3,15-di-O-acetylbruceolide. Two antimalarial drugs used clinically, chloroquine and artemisinin, demonstrated only low activity corresponding to 1/4 and 1/12 of the ED50 value of 3,15-di-O-acetylbruceolide, respectively. These results may be helpful in the design of better chemotherapeutic bruceolides against falciparum malaria. Copyright (C) 2000 Elsevier Science Ireland Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 271-274 |
| Number of pages | 4 |
| Journal | Parasitology International |
| Volume | 48 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jan 1 2000 |
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Keywords
- 3,15-di-O-acetylbruceolide
- Antimalarial agent
- Brucea javanica
- P. berghei
- P. falciparum
ASJC Scopus subject areas
- Parasitology
- Infectious Diseases
Cite this
Potent in vivo antimalarial activity of 3,15-di-O-acetylbruceolide against Plasmodium berghei infection in mice. / Kim, Hye-Sook; Shibata, Yasuharu; Ko, Naoko; Ikemoto, Naomi; Ishizuka, Yuki; Murakami, Nobutoshi; Sugimoto, Masanori; Kobayashi, Motomasa; Wataya, Yusuke.
In: Parasitology International, Vol. 48, No. 3, 01.01.2000, p. 271-274.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Potent in vivo antimalarial activity of 3,15-di-O-acetylbruceolide against Plasmodium berghei infection in mice
AU - Kim, Hye-Sook
AU - Shibata, Yasuharu
AU - Ko, Naoko
AU - Ikemoto, Naomi
AU - Ishizuka, Yuki
AU - Murakami, Nobutoshi
AU - Sugimoto, Masanori
AU - Kobayashi, Motomasa
AU - Wataya, Yusuke
PY - 2000/1/1
Y1 - 2000/1/1
N2 - The antimalarial activity of the O-acylated bruceolide derivative, 3,15-di-O-acetylbruceolide, was evaluated against Plasmodium berghei in vivo. The concentration of 3,15-di-O-acetylbruceolide required for 50% suppression (ED50) of P. berghei in mice was 0.46±0.06 mg/kg/day, whereas bruceolide was only half as effective as 3,15-di-O-acetylbruceolide. Two antimalarial drugs used clinically, chloroquine and artemisinin, demonstrated only low activity corresponding to 1/4 and 1/12 of the ED50 value of 3,15-di-O-acetylbruceolide, respectively. These results may be helpful in the design of better chemotherapeutic bruceolides against falciparum malaria. Copyright (C) 2000 Elsevier Science Ireland Ltd.
AB - The antimalarial activity of the O-acylated bruceolide derivative, 3,15-di-O-acetylbruceolide, was evaluated against Plasmodium berghei in vivo. The concentration of 3,15-di-O-acetylbruceolide required for 50% suppression (ED50) of P. berghei in mice was 0.46±0.06 mg/kg/day, whereas bruceolide was only half as effective as 3,15-di-O-acetylbruceolide. Two antimalarial drugs used clinically, chloroquine and artemisinin, demonstrated only low activity corresponding to 1/4 and 1/12 of the ED50 value of 3,15-di-O-acetylbruceolide, respectively. These results may be helpful in the design of better chemotherapeutic bruceolides against falciparum malaria. Copyright (C) 2000 Elsevier Science Ireland Ltd.
KW - 3,15-di-O-acetylbruceolide
KW - Antimalarial agent
KW - Brucea javanica
KW - P. berghei
KW - P. falciparum
UR - http://www.scopus.com/inward/record.url?scp=0033991555&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033991555&partnerID=8YFLogxK
U2 - 10.1016/S1383-5769(99)00023-9
DO - 10.1016/S1383-5769(99)00023-9
M3 - Article
C2 - 11227768
AN - SCOPUS:0033991555
VL - 48
SP - 271
EP - 274
JO - Parasitology International
JF - Parasitology International
SN - 1383-5769
IS - 3
ER -