Postoperative serum α-fetoprotein level is a useful predictor of recurrence after hepatectomy for hepatocellular carcinoma

Daisuke Nobuoka, Yuichiro Kato, Naoto Gotohda, Shinichiro Takahashi, Toshio Nakagohri, Masaru Konishi, Taira Kinoshita, Tetsuya Nakatsura

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We evaluated the clinical value of perioperative α-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP) levels in predicting recurrence of hepatocellular carcinoma (HCC) after curative resection, with a focus on the time course as surveillance tools. A total of 165 consecutive HCC patients who had undergone curative hepatectomy at our institution from 2005 to 2007 and whose serum AFP and DCP had been measured before and after hepatectomy were included in this study. The minimum postoperative levels within a 4-month period were used for analysis. Among the patients with a positive level of AFP before operation, the number of patients whose AFP level did not change from positive to negative after operation in the group with recurrence exceeded that in the group without recurrence (48/60, 80.0% vs. 4/23, 17.4%), and the difference was significant (P

Original languageEnglish
Pages (from-to)521-528
Number of pages8
JournalOncology Reports
Volume24
Issue number2
DOIs
Publication statusPublished - Aug 2010
Externally publishedYes

Fingerprint

Fetal Proteins
Hepatectomy
Hepatocellular Carcinoma
Prothrombin
Recurrence
Serum

Keywords

  • α-fetoprotein
  • Des-γ-carboxy prothrombin
  • Hepatectomy
  • Hepatocellular carcinoma recurrence
  • Tumor marker

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Nobuoka, D., Kato, Y., Gotohda, N., Takahashi, S., Nakagohri, T., Konishi, M., ... Nakatsura, T. (2010). Postoperative serum α-fetoprotein level is a useful predictor of recurrence after hepatectomy for hepatocellular carcinoma. Oncology Reports, 24(2), 521-528. https://doi.org/10.3892/or-00000888

Postoperative serum α-fetoprotein level is a useful predictor of recurrence after hepatectomy for hepatocellular carcinoma. / Nobuoka, Daisuke; Kato, Yuichiro; Gotohda, Naoto; Takahashi, Shinichiro; Nakagohri, Toshio; Konishi, Masaru; Kinoshita, Taira; Nakatsura, Tetsuya.

In: Oncology Reports, Vol. 24, No. 2, 08.2010, p. 521-528.

Research output: Contribution to journalArticle

Nobuoka, D, Kato, Y, Gotohda, N, Takahashi, S, Nakagohri, T, Konishi, M, Kinoshita, T & Nakatsura, T 2010, 'Postoperative serum α-fetoprotein level is a useful predictor of recurrence after hepatectomy for hepatocellular carcinoma', Oncology Reports, vol. 24, no. 2, pp. 521-528. https://doi.org/10.3892/or-00000888
Nobuoka, Daisuke ; Kato, Yuichiro ; Gotohda, Naoto ; Takahashi, Shinichiro ; Nakagohri, Toshio ; Konishi, Masaru ; Kinoshita, Taira ; Nakatsura, Tetsuya. / Postoperative serum α-fetoprotein level is a useful predictor of recurrence after hepatectomy for hepatocellular carcinoma. In: Oncology Reports. 2010 ; Vol. 24, No. 2. pp. 521-528.
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