Postnatal development of the gastrin-releasing peptide system in the lumbosacral spinal cord controlling male reproductive function in rats

Nao Katayama, Takumi Oti, Keiko Takanami, Tatsuya Sakamoto, Hirotaka Sakamoto

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A sexually dimorphic spinal gastrin-releasing peptide (GRP) system in the lumbosacral spinal cord, which projects to the lower spinal centers, controls erection and ejaculation in rats. However, little is known about the postnatal development of this system. In this study, we therefore examined the postnatal development of the male-dominant spinal GRP system and its sexual differentiation in rats using immunohistochemistry. Our results show that male-dominant expression of GRP is prominent from the onset of puberty and that sexually dimorphism persists into adulthood. These results suggest that androgen surge during male puberty plays an important role in the development and maintenance of the male-specific GRP function in the rat spinal cord.

Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalProceedings of the Japan Academy Series B: Physical and Biological Sciences
Volume92
Issue number2
DOIs
Publication statusPublished - 2016

Fingerprint

gastrin-releasing peptide
Gastrin-Releasing Peptide
spinal cord
postnatal development
releasing
rats
peptides
Spinal Cord
puberty
Puberty
Sex Differentiation
Ejaculation
ejaculation
sexual development
androgens
dimorphism
adulthood
Androgens
maintenance
immunohistochemistry

Keywords

  • Androgens
  • Gastrin-releasing peptide
  • Male sexual behavior
  • Puberty
  • Sexual differentiation
  • Spinal cord

ASJC Scopus subject areas

  • General

Cite this

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abstract = "A sexually dimorphic spinal gastrin-releasing peptide (GRP) system in the lumbosacral spinal cord, which projects to the lower spinal centers, controls erection and ejaculation in rats. However, little is known about the postnatal development of this system. In this study, we therefore examined the postnatal development of the male-dominant spinal GRP system and its sexual differentiation in rats using immunohistochemistry. Our results show that male-dominant expression of GRP is prominent from the onset of puberty and that sexually dimorphism persists into adulthood. These results suggest that androgen surge during male puberty plays an important role in the development and maintenance of the male-specific GRP function in the rat spinal cord.",
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AU - Oti, Takumi

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AU - Sakamoto, Tatsuya

AU - Sakamoto, Hirotaka

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