Abstract
Autoimmunity is still a mystery of clinical immunology and medicine as a whole. The etiology and pathogenesis of autoimmune disorders remain unclear and, thus, are assessed as a balance between hereditary predisposition, triggering factors and the appearance of autoantibodies and/or self-reactive T cells. Among the immunological armamentarium, molecular mimicry, based on self-reactive T- and B-cell activation by cross-reactive epitopes of infectious agents, is of special value. Hypotheses regarding the possible involvement of molecular mimicry in the development of postinfectious autoimmunity are currently very intriguing. They provide new approaches for identifying etiological agents that are associated with postinfectious autoimmunity, paired microbial- and tissue-linked epitopes targeted for autoimmune reaction determination, postinfectious autoimmunity pathogenesis recognition and specific prevention, and therapy for autoimmune disorder development.
| Original language | English |
|---|---|
| Pages (from-to) | 323-331 |
| Number of pages | 9 |
| Journal | Expert Review of Clinical Immunology |
| Volume | 3 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 2007 |
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Keywords
- Autoantibodies
- Autoimmune disorders
- Molecular mimicry
- Postinfectious autoimmunity
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Postinfectious immunodeficiency and autoimmunity : Pathogenic and clinical values and implications. / Khitrov, Alexander N.; Shogenov, Zaur S.; Tretyak, Eugenia B.; Ischenko, Anatoly I.; Matsuura, Eiji; Neuhaus, Oliver; Paltsev, Mikhail A.; Suchkov, Sergey V.
In: Expert Review of Clinical Immunology, Vol. 3, No. 3, 05.2007, p. 323-331.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Postinfectious immunodeficiency and autoimmunity
T2 - Pathogenic and clinical values and implications
AU - Khitrov, Alexander N.
AU - Shogenov, Zaur S.
AU - Tretyak, Eugenia B.
AU - Ischenko, Anatoly I.
AU - Matsuura, Eiji
AU - Neuhaus, Oliver
AU - Paltsev, Mikhail A.
AU - Suchkov, Sergey V.
PY - 2007/5
Y1 - 2007/5
N2 - Autoimmunity is still a mystery of clinical immunology and medicine as a whole. The etiology and pathogenesis of autoimmune disorders remain unclear and, thus, are assessed as a balance between hereditary predisposition, triggering factors and the appearance of autoantibodies and/or self-reactive T cells. Among the immunological armamentarium, molecular mimicry, based on self-reactive T- and B-cell activation by cross-reactive epitopes of infectious agents, is of special value. Hypotheses regarding the possible involvement of molecular mimicry in the development of postinfectious autoimmunity are currently very intriguing. They provide new approaches for identifying etiological agents that are associated with postinfectious autoimmunity, paired microbial- and tissue-linked epitopes targeted for autoimmune reaction determination, postinfectious autoimmunity pathogenesis recognition and specific prevention, and therapy for autoimmune disorder development.
AB - Autoimmunity is still a mystery of clinical immunology and medicine as a whole. The etiology and pathogenesis of autoimmune disorders remain unclear and, thus, are assessed as a balance between hereditary predisposition, triggering factors and the appearance of autoantibodies and/or self-reactive T cells. Among the immunological armamentarium, molecular mimicry, based on self-reactive T- and B-cell activation by cross-reactive epitopes of infectious agents, is of special value. Hypotheses regarding the possible involvement of molecular mimicry in the development of postinfectious autoimmunity are currently very intriguing. They provide new approaches for identifying etiological agents that are associated with postinfectious autoimmunity, paired microbial- and tissue-linked epitopes targeted for autoimmune reaction determination, postinfectious autoimmunity pathogenesis recognition and specific prevention, and therapy for autoimmune disorder development.
KW - Autoantibodies
KW - Autoimmune disorders
KW - Molecular mimicry
KW - Postinfectious autoimmunity
UR - http://www.scopus.com/inward/record.url?scp=34249706791&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34249706791&partnerID=8YFLogxK
U2 - 10.1586/1744666X.3.3.323
DO - 10.1586/1744666X.3.3.323
M3 - Article
C2 - 20477676
AN - SCOPUS:34249706791
VL - 3
SP - 323
EP - 331
JO - Expert Review of Clinical Immunology
JF - Expert Review of Clinical Immunology
SN - 1744-666X
IS - 3
ER -