TY - JOUR
T1 - Postinfectious immunodeficiency and autoimmunity
T2 - Pathogenic and clinical values and implications
AU - Khitrov, Alexander N.
AU - Shogenov, Zaur S.
AU - Tretyak, Eugenia B.
AU - Ischenko, Anatoly I.
AU - Matsuura, Eiji
AU - Neuhaus, Oliver
AU - Paltsev, Mikhail A.
AU - Suchkov, Sergey V.
N1 - Funding Information:
Zaur S Shogenov, MD, PhD Associate Professor, Russian State Medical University at Moscow Municipal Clinical Hospital No. 81, Department of Cardiology, Moscow, Russia Tel.: +7 495 708 3765 Fax: +7 495 242 9130 zshogenov@kmail.ru Eugenia B Tretyak, MD Assistant Professor, Russian State Biomedical and Emergency Agency at Federal Clinical Hospital No. 83, Department of Ophthalmic Diseases, Russia Tel.: +7 495 471 3511 Fax: +7 495 471 3511 tretyak_eugenia@mail.ru Anatoly I Ischenko, MD, PhD Professor in Obstetrics and Gynecology, and Chairman of Department of Obstetrics and Gynecology, IM Sechenov Moscow Medical Academy, Moscow, Russia Tel.: +7 495 248 6956 Fax: +7 495 248 0223 mma-sechenov@mtu-net.ru Eiji Matsuura, MD, PhD Associate Professor, Okayama University, Graduate School of Medicine and Dentistry, Department of Cell Chemistry, Okayama, Japan Tel.: +81 862 357 402 Fax: +81 862 357 404 eijimatu@md.okayama-u.ac.jp
PY - 2007/5
Y1 - 2007/5
N2 - Autoimmunity is still a mystery of clinical immunology and medicine as a whole. The etiology and pathogenesis of autoimmune disorders remain unclear and, thus, are assessed as a balance between hereditary predisposition, triggering factors and the appearance of autoantibodies and/or self-reactive T cells. Among the immunological armamentarium, molecular mimicry, based on self-reactive T- and B-cell activation by cross-reactive epitopes of infectious agents, is of special value. Hypotheses regarding the possible involvement of molecular mimicry in the development of postinfectious autoimmunity are currently very intriguing. They provide new approaches for identifying etiological agents that are associated with postinfectious autoimmunity, paired microbial- and tissue-linked epitopes targeted for autoimmune reaction determination, postinfectious autoimmunity pathogenesis recognition and specific prevention, and therapy for autoimmune disorder development.
AB - Autoimmunity is still a mystery of clinical immunology and medicine as a whole. The etiology and pathogenesis of autoimmune disorders remain unclear and, thus, are assessed as a balance between hereditary predisposition, triggering factors and the appearance of autoantibodies and/or self-reactive T cells. Among the immunological armamentarium, molecular mimicry, based on self-reactive T- and B-cell activation by cross-reactive epitopes of infectious agents, is of special value. Hypotheses regarding the possible involvement of molecular mimicry in the development of postinfectious autoimmunity are currently very intriguing. They provide new approaches for identifying etiological agents that are associated with postinfectious autoimmunity, paired microbial- and tissue-linked epitopes targeted for autoimmune reaction determination, postinfectious autoimmunity pathogenesis recognition and specific prevention, and therapy for autoimmune disorder development.
KW - Autoantibodies
KW - Autoimmune disorders
KW - Molecular mimicry
KW - Postinfectious autoimmunity
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U2 - 10.1586/1744666X.3.3.323
DO - 10.1586/1744666X.3.3.323
M3 - Review article
C2 - 20477676
AN - SCOPUS:34249706791
VL - 3
SP - 323
EP - 331
JO - Expert Review of Clinical Immunology
JF - Expert Review of Clinical Immunology
SN - 1744-666X
IS - 3
ER -