Postinfectious immunodeficiency and autoimmunity: Pathogenic and clinical values and implications

Alexander N. Khitrov, Zaur S. Shogenov, Eugenia B. Tretyak, Anatoly I. Ischenko, Eiji Matsuura, Oliver Neuhaus, Mikhail A. Paltsev, Sergey V. Suchkov

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Autoimmunity is still a mystery of clinical immunology and medicine as a whole. The etiology and pathogenesis of autoimmune disorders remain unclear and, thus, are assessed as a balance between hereditary predisposition, triggering factors and the appearance of autoantibodies and/or self-reactive T cells. Among the immunological armamentarium, molecular mimicry, based on self-reactive T- and B-cell activation by cross-reactive epitopes of infectious agents, is of special value. Hypotheses regarding the possible involvement of molecular mimicry in the development of postinfectious autoimmunity are currently very intriguing. They provide new approaches for identifying etiological agents that are associated with postinfectious autoimmunity, paired microbial- and tissue-linked epitopes targeted for autoimmune reaction determination, postinfectious autoimmunity pathogenesis recognition and specific prevention, and therapy for autoimmune disorder development.

Original languageEnglish
Pages (from-to)323-331
Number of pages9
JournalExpert Review of Clinical Immunology
Volume3
Issue number3
DOIs
Publication statusPublished - May 2007

Keywords

  • Autoantibodies
  • Autoimmune disorders
  • Molecular mimicry
  • Postinfectious autoimmunity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Khitrov, A. N., Shogenov, Z. S., Tretyak, E. B., Ischenko, A. I., Matsuura, E., Neuhaus, O., Paltsev, M. A., & Suchkov, S. V. (2007). Postinfectious immunodeficiency and autoimmunity: Pathogenic and clinical values and implications. Expert Review of Clinical Immunology, 3(3), 323-331. https://doi.org/10.1586/1744666X.3.3.323