Postextrasystolic Contractility Normally Decays in Alternans in Canine In Situ Heart

Juichiro Shimizu, Satoshi Mohri, Gentaro Iribe, Yutaka Kitagawa, Haruo Ito, Junichi Araki, Miyako Takaki, Hiroyuki Suga

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We have reported that the postextrasystolic (PES) potentiation of left ventricular (LV) contractility usually decays in alternans at heart rates above 80-100beats/min in the canine excised, cross-circulated heart. We examined whether the PES contractility would also decay in alternans even in the canine in situ heart presumably more physiological than the excised heart. In anesthetized, ventilated, and open-chest mongrel dogs, we measured LV pressure and volume with a micromanometer and a conductance catheter cannulated into the LV and obtained LV end-systolic maximum elastance (Emax) as the reasonably load-independent contractility index. We inserted an extrasystole followed by a compensatory pause into steady-state regular beats at heart rates above 90beats/min and analyzed the PES decay pattern of Emax. We found that Emax potentiated in the first PES beat decayed in alternans within 5-6 PES beats. This indicates that PES contractility also decays in alternans in the normal canine in situ heart.

Original languageEnglish
Pages (from-to)313-318
Number of pages6
JournalJapanese journal of physiology
Volume53
Issue number4
DOIs
Publication statusPublished - Aug 2003

Keywords

  • Arrhythmia
  • Ca recirculation
  • Compensatory pause
  • E
  • Pressure-volume loop

ASJC Scopus subject areas

  • Physiology

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    Shimizu, J., Mohri, S., Iribe, G., Kitagawa, Y., Ito, H., Araki, J., Takaki, M., & Suga, H. (2003). Postextrasystolic Contractility Normally Decays in Alternans in Canine In Situ Heart. Japanese journal of physiology, 53(4), 313-318. https://doi.org/10.2170/jjphysiol.53.313