TY - JOUR
T1 - Post-relapse survival in patients with the early and late distant recurrence in estrogen receptor-positive HER2-negative breast cancer
AU - Collaborative Study Group of Scientific Research of the Japanese Breast Cancer Society
AU - Ogiya, Akiko
AU - Yamazaki, Kieko
AU - Horii, Rie
AU - Shien, Tadahiko
AU - Horimoto, Yoshiya
AU - Masuda, Norikazu
AU - Inao, Touko
AU - Hosoda, Mitsuchika
AU - Ishida, Naoko
AU - Osako, Tomofumi
AU - Takahashi, Masato
AU - Endo, Yumi
AU - Miyoshi, Yuichiro
AU - Yasojima, Hiroyuki
AU - Tomioka, Nobumoto
AU - Yamashita, Hiroko
N1 - Funding Information:
This study was supported by a Grant-in-Aid for Scientific Research from the Japanese Breast Cancer Society.
Publisher Copyright:
© 2016, The Japanese Breast Cancer Society.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Background: Few studies have been performed on post-relapse survival in patients with the early and late distant recurrence in estrogen receptor (ER)-positive, HER2-negative breast cancer. Methods: A total of 205 patients with the early distant recurrence and 134 patients with the late distant recurrence of ER-positive, HER2-negative breast cancer who had undergone breast surgery or neoadjuvant chemotherapy between January 2000 and December 2004 were registered from nine institutions. Prognostic factors for post-relapse survival in patients with the early and late recurrence were analyzed. Results: Post-relapse survival was significantly longer in patients with the late recurrence than in patients with the early recurrence. Predictive factors for post-relapse survival in patients with the early recurrence were lack of adjuvant chemotherapy, a long disease-free interval, and long durations of endocrine therapies and chemotherapies after relapse. In patients with the late recurrence, post-relapse survival was significantly improved for those individuals with one metastatic organ at relapse and individuals who were treated with the first-line and subsequent endocrine therapies for prolonged periods. Moreover, ER expression in primary breast tumors of late recurrence patients was significantly higher with a duration of the first-line endocrine therapy >6 months than in those with a duration ≤6 months. Conclusion: Predictors for prognosis after relapse differed between patients with the early and late distant recurrence. Endocrine responsiveness after relapse is a key factor for improved post-relapse survival, and it is thus important to establish whether metastatic tumors are endocrine-resistant in ER-positive, HER2-negative recurrent breast cancer.
AB - Background: Few studies have been performed on post-relapse survival in patients with the early and late distant recurrence in estrogen receptor (ER)-positive, HER2-negative breast cancer. Methods: A total of 205 patients with the early distant recurrence and 134 patients with the late distant recurrence of ER-positive, HER2-negative breast cancer who had undergone breast surgery or neoadjuvant chemotherapy between January 2000 and December 2004 were registered from nine institutions. Prognostic factors for post-relapse survival in patients with the early and late recurrence were analyzed. Results: Post-relapse survival was significantly longer in patients with the late recurrence than in patients with the early recurrence. Predictive factors for post-relapse survival in patients with the early recurrence were lack of adjuvant chemotherapy, a long disease-free interval, and long durations of endocrine therapies and chemotherapies after relapse. In patients with the late recurrence, post-relapse survival was significantly improved for those individuals with one metastatic organ at relapse and individuals who were treated with the first-line and subsequent endocrine therapies for prolonged periods. Moreover, ER expression in primary breast tumors of late recurrence patients was significantly higher with a duration of the first-line endocrine therapy >6 months than in those with a duration ≤6 months. Conclusion: Predictors for prognosis after relapse differed between patients with the early and late distant recurrence. Endocrine responsiveness after relapse is a key factor for improved post-relapse survival, and it is thus important to establish whether metastatic tumors are endocrine-resistant in ER-positive, HER2-negative recurrent breast cancer.
KW - Breast cancer
KW - Endocrine therapy
KW - Estrogen receptor-positive
KW - Post-relapse survival
KW - Prognosis
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U2 - 10.1007/s12282-016-0730-3
DO - 10.1007/s12282-016-0730-3
M3 - Article
C2 - 27628678
AN - SCOPUS:84988443341
VL - 24
SP - 473
EP - 482
JO - Breast Cancer
JF - Breast Cancer
SN - 1340-6868
IS - 3
ER -