Post-ischemic administration of bifemelane hydrochloride prohibits ischemia-induced depletion of the muscarinic M1-receptor and its mRNA in the gerbil hippocampus

N. Ogawa, M. Asanuma, K. Mizukawa, H. Hirata, H. Chou, A. Mori

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Parallel determinations of muscarinic cholinergic M1 receptor (M1-R) binding and of M1-R mRNA levels were carried out in the gerbil hippocampus 14 days after 5 min of transient ischemia. Both were reduced in the ischemic tissue to about 50% of the levels found in sham-operated controls, indicating that the late loss of M1-R is probably decreased synthesis. Three administrations of bifemelane hydrochloride (15 mg/kg, i.p., just after ischemia and 6 and 12 h later) completely prevented neuronal death in the hippocampus and ischemia-induced losses of hippocampal M1-R and its mRNA. Since vascular dementia may depend upon the ischemia-induced losses in cholinergic communication in the hippocampus, these findings suggest that it may be possible to prevent its occurrence by post-ischemic treatment with bifemelane hydrochloride.

Original languageEnglish
Pages (from-to)171-175
Number of pages5
JournalBrain Research
Volume591
Issue number1
DOIs
Publication statusPublished - Sep 18 1992

Keywords

  • Bifemelane hydrochloride
  • Ischemia-induced depletion
  • Muscarinic M receptor
  • Muscarinic M-receptor messenger RNA
  • Post-ischemic administration
  • Prevention

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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