Abstract
Insulin-like factor 3 (INSL3) is a local regulator in mammalian gonads, but little is known of its function in bovine corpus luteum (CL). Here, we show that RXFP2 protein, the receptor of INSL3, was expressed throughout the estrous cycle and significantly high at the early luteal stage compared to the regressed luteal stage. INSL3 stimulated progesterone secretion, but not prostaglandin F2α and viability in cultured luteal cells. Together, these results suggest that INSL3 plays a luteotropic role as a local regulator in the bovine CL.
| Original language | English |
|---|---|
| Pages (from-to) | 629-632 |
| Number of pages | 4 |
| Journal | Journal of Veterinary Medical Science |
| Volume | 75 |
| Issue number | 5 |
| DOIs |
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| Publication status | Published - Jun 6 2013 |
Keywords
- Bovine
- Corpus luteum
- Estrous cycle
- Insulin-like factor 3
- Insulin-like factor 3 receptor
ASJC Scopus subject areas
- veterinary(all)
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Cite this
Abe, M., Hojo, T., Kozai, K., & Okuda, K. (2013). Possible role of insulin-like factor 3 in the bovine corpus luteum. Journal of Veterinary Medical Science, 75(5), 629-632. https://doi.org/10.1292/jvms.12-0423