Possible role of insulin-like factor 3 in the bovine corpus luteum

Misato Abe, Takuo Hojo, Keisuke Kozai, Kiyoshi Okuda

Research output: Contribution to journalComment/debatepeer-review

4 Citations (Scopus)


Insulin-like factor 3 (INSL3) is a local regulator in mammalian gonads, but little is known of its function in bovine corpus luteum (CL). Here, we show that RXFP2 protein, the receptor of INSL3, was expressed throughout the estrous cycle and significantly high at the early luteal stage compared to the regressed luteal stage. INSL3 stimulated progesterone secretion, but not prostaglandin F2α and viability in cultured luteal cells. Together, these results suggest that INSL3 plays a luteotropic role as a local regulator in the bovine CL.

Original languageEnglish
Pages (from-to)629-632
Number of pages4
JournalJournal of Veterinary Medical Science
Issue number5
Publication statusPublished - Jun 6 2013


  • Bovine
  • Corpus luteum
  • Estrous cycle
  • Insulin-like factor 3
  • Insulin-like factor 3 receptor

ASJC Scopus subject areas

  • veterinary(all)


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