TY - JOUR
T1 - Possible role of insulin-like factor 3 in the bovine corpus luteum
AU - Abe, Misato
AU - Hojo, Takuo
AU - Kozai, Keisuke
AU - Okuda, Kiyoshi
PY - 2013/6/6
Y1 - 2013/6/6
N2 - Insulin-like factor 3 (INSL3) is a local regulator in mammalian gonads, but little is known of its function in bovine corpus luteum (CL). Here, we show that RXFP2 protein, the receptor of INSL3, was expressed throughout the estrous cycle and significantly high at the early luteal stage compared to the regressed luteal stage. INSL3 stimulated progesterone secretion, but not prostaglandin F2α and viability in cultured luteal cells. Together, these results suggest that INSL3 plays a luteotropic role as a local regulator in the bovine CL.
AB - Insulin-like factor 3 (INSL3) is a local regulator in mammalian gonads, but little is known of its function in bovine corpus luteum (CL). Here, we show that RXFP2 protein, the receptor of INSL3, was expressed throughout the estrous cycle and significantly high at the early luteal stage compared to the regressed luteal stage. INSL3 stimulated progesterone secretion, but not prostaglandin F2α and viability in cultured luteal cells. Together, these results suggest that INSL3 plays a luteotropic role as a local regulator in the bovine CL.
KW - Bovine
KW - Corpus luteum
KW - Estrous cycle
KW - Insulin-like factor 3
KW - Insulin-like factor 3 receptor
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U2 - 10.1292/jvms.12-0423
DO - 10.1292/jvms.12-0423
M3 - Comment/debate
C2 - 23220928
AN - SCOPUS:84878458937
VL - 75
SP - 629
EP - 632
JO - Journal of Veterinary Medical Science
JF - Journal of Veterinary Medical Science
SN - 0916-7250
IS - 5
ER -