Possible role of insulin-like factor 3 in the bovine corpus luteum

Misato Abe; Takuo Hojo; Keisuke Kozai; Kiyoshi Okuda

doi:10.1292/jvms.12-0423

Possible role of insulin-like factor 3 in the bovine corpus luteum

Misato Abe, Takuo Hojo, Keisuke Kozai, Kiyoshi Okuda

Faculty of Agriculture

Research output: Contribution to journal › Comment/debate › peer-review

1 Citation (Scopus)

Abstract

Insulin-like factor 3 (INSL3) is a local regulator in mammalian gonads, but little is known of its function in bovine corpus luteum (CL). Here, we show that RXFP2 protein, the receptor of INSL3, was expressed throughout the estrous cycle and significantly high at the early luteal stage compared to the regressed luteal stage. INSL3 stimulated progesterone secretion, but not prostaglandin F2α and viability in cultured luteal cells. Together, these results suggest that INSL3 plays a luteotropic role as a local regulator in the bovine CL.

Original language	English
Pages (from-to)	629-632
Number of pages	4
Journal	Journal of Veterinary Medical Science
Volume	75
Issue number	5
DOIs	https://doi.org/10.1292/jvms.12-0423
Publication status	Published - Jun 6 2013

Keywords

Bovine
Corpus luteum
Estrous cycle
Insulin-like factor 3
Insulin-like factor 3 receptor

ASJC Scopus subject areas

veterinary(all)

Access to Document

10.1292/jvms.12-0423

Fingerprint Dive into the research topics of 'Possible role of insulin-like factor 3 in the bovine corpus luteum'. Together they form a unique fingerprint.

Cite this

@article{8126382f4cf64e8dbf7f02eb16d598ea,

title = "Possible role of insulin-like factor 3 in the bovine corpus luteum",

abstract = "Insulin-like factor 3 (INSL3) is a local regulator in mammalian gonads, but little is known of its function in bovine corpus luteum (CL). Here, we show that RXFP2 protein, the receptor of INSL3, was expressed throughout the estrous cycle and significantly high at the early luteal stage compared to the regressed luteal stage. INSL3 stimulated progesterone secretion, but not prostaglandin F2α and viability in cultured luteal cells. Together, these results suggest that INSL3 plays a luteotropic role as a local regulator in the bovine CL.",

keywords = "Bovine, Corpus luteum, Estrous cycle, Insulin-like factor 3, Insulin-like factor 3 receptor",

author = "Misato Abe and Takuo Hojo and Keisuke Kozai and Kiyoshi Okuda",

year = "2013",

month = jun,

day = "6",

doi = "10.1292/jvms.12-0423",

language = "English",

volume = "75",

pages = "629--632",

journal = "Journal of Veterinary Medical Science",

issn = "0916-7250",

publisher = "Japanese Society of Veterinary Science",

number = "5",

}

TY - JOUR

T1 - Possible role of insulin-like factor 3 in the bovine corpus luteum

AU - Abe, Misato

AU - Hojo, Takuo

AU - Kozai, Keisuke

AU - Okuda, Kiyoshi

PY - 2013/6/6

Y1 - 2013/6/6

N2 - Insulin-like factor 3 (INSL3) is a local regulator in mammalian gonads, but little is known of its function in bovine corpus luteum (CL). Here, we show that RXFP2 protein, the receptor of INSL3, was expressed throughout the estrous cycle and significantly high at the early luteal stage compared to the regressed luteal stage. INSL3 stimulated progesterone secretion, but not prostaglandin F2α and viability in cultured luteal cells. Together, these results suggest that INSL3 plays a luteotropic role as a local regulator in the bovine CL.

AB - Insulin-like factor 3 (INSL3) is a local regulator in mammalian gonads, but little is known of its function in bovine corpus luteum (CL). Here, we show that RXFP2 protein, the receptor of INSL3, was expressed throughout the estrous cycle and significantly high at the early luteal stage compared to the regressed luteal stage. INSL3 stimulated progesterone secretion, but not prostaglandin F2α and viability in cultured luteal cells. Together, these results suggest that INSL3 plays a luteotropic role as a local regulator in the bovine CL.

KW - Bovine

KW - Corpus luteum

KW - Estrous cycle

KW - Insulin-like factor 3

KW - Insulin-like factor 3 receptor

UR - http://www.scopus.com/inward/record.url?scp=84878458937&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878458937&partnerID=8YFLogxK

U2 - 10.1292/jvms.12-0423

DO - 10.1292/jvms.12-0423

M3 - Comment/debate

C2 - 23220928

AN - SCOPUS:84878458937

VL - 75

SP - 629

EP - 632

JO - Journal of Veterinary Medical Science

JF - Journal of Veterinary Medical Science

SN - 0916-7250

IS - 5

ER -