Possible modulation of process extension by N-methyl-D-aspartate receptor expressed in osteocytic MLO-Y4 cells

Hiroyuki Fujita, Eiichi Hinoi, Eri Nakatani, Tomomi Yamamoto, Takeshi Takarada, Yukio Yoneda

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In contrast to osteoblasts, little attention has been paid to expression profiles of different glutamatergic signaling machineries in osteocytes, which are the most abundant cells with a possible role as a mechanical sensor in bone. Here, we show that N-methyl-D-aspartate receptor (NMDAR) is expressed by osteocytic cells in five-weeks-old mouse tibiae in vivo as well as by osteocytic MLO-Y4 cells in vitro. Sustained exposure to the NMDAR antagonist dizocilpine significantly increased the number of cells with processes in cultured MLO-Y4 cells. These results suggest that NMDAR would be expressed by osteocytes with an unidentified role in the process extension.

Original languageEnglish
Pages (from-to)112-116
Number of pages5
JournalJournal of Pharmacological Sciences
Volume119
Issue number1
DOIs
Publication statusPublished - 2012

Keywords

  • N-methyl-D-aspartate receptor
  • Osteocyte
  • Process extension

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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