Possible mechanism underlying high-pressure unfolding of proteins: Formation of a short-period high-density hydration shell

Tomonari Sumi; Hideo Sekino

doi:10.1039/c1cp21347d

Possible mechanism underlying high-pressure unfolding of proteins: Formation of a short-period high-density hydration shell

Tomonari Sumi, Hideo Sekino

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Hydration effects on high-pressure unfolding of a hydrophobic polymer chain are investigated through a multiscale simulation based on density-functional theory. The results strongly suggest the following: a thermodynamic origin for high-pressure denaturation, i.e., the decrease in volume due to the unfolding can be explained by the formation of a short-period high-density hydration shell.

Original language	English
Pages (from-to)	15829-15832
Number of pages	4
Journal	Physical Chemistry Chemical Physics
Volume	13
Issue number	35
DOIs	https://doi.org/10.1039/c1cp21347d
Publication status	Published - Sep 21 2011
Externally published	Yes

ASJC Scopus subject areas

Physics and Astronomy(all)
Physical and Theoretical Chemistry

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abstract = "Hydration effects on high-pressure unfolding of a hydrophobic polymer chain are investigated through a multiscale simulation based on density-functional theory. The results strongly suggest the following: a thermodynamic origin for high-pressure denaturation, i.e., the decrease in volume due to the unfolding can be explained by the formation of a short-period high-density hydration shell.",

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Possible mechanism underlying high-pressure unfolding of proteins: Formation of a short-period high-density hydration shell

Abstract

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