Abstract
Hydration effects on high-pressure unfolding of a hydrophobic polymer chain are investigated through a multiscale simulation based on density-functional theory. The results strongly suggest the following: a thermodynamic origin for high-pressure denaturation, i.e., the decrease in volume due to the unfolding can be explained by the formation of a short-period high-density hydration shell.
Original language | English |
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Pages (from-to) | 15829-15832 |
Number of pages | 4 |
Journal | Physical Chemistry Chemical Physics |
Volume | 13 |
Issue number | 35 |
DOIs | |
Publication status | Published - Sep 21 2011 |
Externally published | Yes |
ASJC Scopus subject areas
- Physics and Astronomy(all)
- Physical and Theoretical Chemistry