Possible involvement of protein kinase C and low molecular weight GTP-binding proteins in thrombin-induced histamine secretion in human platelets

Takashi Uehara, Yoshinon Kitayama, Yoshihisa Kitamura, Yasuyuki Nomura

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Thrombin and 12-O-tetradecanoylphorbol 13-acetate (TPA) caused histamine secretion from human platelets. To clarify the intracellular signalling mechanism of thrombin-induced histamine secretion, the effects of pertussis toxin (PTX) and botulinus toxin (BTX) on thrombin- and TPA-induced histamine secretion were examined in human platelets. The secretion by thrombin was sensitive to BTX, but not PTX. The secretion by TPA was also inhibited by BTX. These results suggest that protein kinase C and low molecular weight G-proteins sensitive to BTX are involved in histamine secretion.

Original languageEnglish
Pages (from-to)492-496
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume206
Issue number2
DOIs
Publication statusPublished - Jan 17 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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