Possible involvement of p38 MAP kinase in HSP70 expression induced by hypoxia in rat primary astrocytes

Takashi Uehara, Masayuki Kaneko, Shinji Tanaka, Yasunobu Okuma, Yasuyuki Nomura

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)

Abstract

The aim of this study was to elucidate the possible mechanism of HSP induction in response to hypoxia in rat primary astrocytes. Treatment with SB203580, a selective p38 MAP kinase (p38 MAPK) inhibitor, attenuated the increase in HSP70 in a concentration-dependent manner, p38 MAPK was activated in response to hypoxic treatment. These results suggest that p38 MAPK positively regulates hypoxia-induced HSP70 expression in astrocytes.

Original languageEnglish
Pages (from-to)226-230
Number of pages5
JournalBrain Research
Volume823
Issue number1-2
DOIs
Publication statusPublished - Mar 27 1999
Externally publishedYes

Keywords

  • Astrocyte
  • HSP70
  • Hypoxia
  • Ischemia
  • p38 MAP kinase

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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