Possible contribution of prior hepatitis B virus infection to the development of hepatocellular carcinoma

Hironori Tanaka, Yoshiaki Iwasaki, Kazuhiro Nouso, Yoshiyuki Kobayashi, Shin Ichiro Nakamura, Eiji Matsumoto, Nobuyuki Toshikuni, Toshihiko Kaneyoshi, Toshiya Ohsawa, Kouichi Takaguchi, Kozo Fujio, Tomonori Senoh, Tohru Ohnishi, Kohsaku Sakaguchi, Yasushi Shiratori

Research output: Contribution to journalArticle

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Abstract

Background: The prevalence of prior hepatitis B virus (HBV) infection in hepatocellular carcinoma (HCC) patients and its role in hepatocarcinogenesis are not clear. The aim of the present study is to clarify the importance of prior HBV infection in development of HCC. Methods: Of 1288 consecutive HCC patients between January 1999 and October 2002, 1008 patients were enrolled. To determine the influence of prior HBV infection in hepatitis B surface antigen (HBsAg)-negative HCC, the prevalence of antibody to hepatitis B core antigen (anti-HBc) was examined according to age, and the clinical features were compared between the anti-HBc positive and the negative groups. Results: The proportion of HBsAg-negative HCC patients, HCC patients with antibody to hepatitis C virus (anti-HCV; C-HCC) and HCC patients negative for both HBsAg and anti-HCV (nBnC-HCC), increased with age. The anti-HBc-positive rates in C-HCC patients also increased with age. Those rates in nBnC-HCC patients were >50% in all age groups. Furthermore, it was found that the anti-HBc-positive rates of these patients were higher than those of corresponding control patients. Tumor size and a positive rate for vessel involvement both in C-HCC and nBnC-HCC patients were larger and higher, respectively, in anti-HBc-positive patients compared with anti-HBc-negative patients, although the difference in nBnC-HCC did not reach statistical significance because of the small numbers. These tumor characteristics were similar to those of B-HCC patients. Conclusion: A possible contribution of prior HBV infection to the development of HCC is indicated.

Original languageEnglish
Pages (from-to)850-856
Number of pages7
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume20
Issue number6
DOIs
Publication statusPublished - 2005

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Virus Diseases
Hepatitis B virus
Hepatocellular Carcinoma
Hepatitis B Core Antigens
Antibodies
Hepatitis B Surface Antigens
Hepatitis C Antibodies

Keywords

  • Antibody to hepatitis B core antigen
  • Hepatitis B
  • Hepatocellular carcinoma
  • Occult HBV infection
  • Prior HBV infection

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Possible contribution of prior hepatitis B virus infection to the development of hepatocellular carcinoma. / Tanaka, Hironori; Iwasaki, Yoshiaki; Nouso, Kazuhiro; Kobayashi, Yoshiyuki; Nakamura, Shin Ichiro; Matsumoto, Eiji; Toshikuni, Nobuyuki; Kaneyoshi, Toshihiko; Ohsawa, Toshiya; Takaguchi, Kouichi; Fujio, Kozo; Senoh, Tomonori; Ohnishi, Tohru; Sakaguchi, Kohsaku; Shiratori, Yasushi.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 20, No. 6, 2005, p. 850-856.

Research output: Contribution to journalArticle

Tanaka, H, Iwasaki, Y, Nouso, K, Kobayashi, Y, Nakamura, SI, Matsumoto, E, Toshikuni, N, Kaneyoshi, T, Ohsawa, T, Takaguchi, K, Fujio, K, Senoh, T, Ohnishi, T, Sakaguchi, K & Shiratori, Y 2005, 'Possible contribution of prior hepatitis B virus infection to the development of hepatocellular carcinoma', Journal of Gastroenterology and Hepatology (Australia), vol. 20, no. 6, pp. 850-856. https://doi.org/10.1111/j.1400-1746.2005.03823.x
Tanaka, Hironori ; Iwasaki, Yoshiaki ; Nouso, Kazuhiro ; Kobayashi, Yoshiyuki ; Nakamura, Shin Ichiro ; Matsumoto, Eiji ; Toshikuni, Nobuyuki ; Kaneyoshi, Toshihiko ; Ohsawa, Toshiya ; Takaguchi, Kouichi ; Fujio, Kozo ; Senoh, Tomonori ; Ohnishi, Tohru ; Sakaguchi, Kohsaku ; Shiratori, Yasushi. / Possible contribution of prior hepatitis B virus infection to the development of hepatocellular carcinoma. In: Journal of Gastroenterology and Hepatology (Australia). 2005 ; Vol. 20, No. 6. pp. 850-856.
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abstract = "Background: The prevalence of prior hepatitis B virus (HBV) infection in hepatocellular carcinoma (HCC) patients and its role in hepatocarcinogenesis are not clear. The aim of the present study is to clarify the importance of prior HBV infection in development of HCC. Methods: Of 1288 consecutive HCC patients between January 1999 and October 2002, 1008 patients were enrolled. To determine the influence of prior HBV infection in hepatitis B surface antigen (HBsAg)-negative HCC, the prevalence of antibody to hepatitis B core antigen (anti-HBc) was examined according to age, and the clinical features were compared between the anti-HBc positive and the negative groups. Results: The proportion of HBsAg-negative HCC patients, HCC patients with antibody to hepatitis C virus (anti-HCV; C-HCC) and HCC patients negative for both HBsAg and anti-HCV (nBnC-HCC), increased with age. The anti-HBc-positive rates in C-HCC patients also increased with age. Those rates in nBnC-HCC patients were >50{\%} in all age groups. Furthermore, it was found that the anti-HBc-positive rates of these patients were higher than those of corresponding control patients. Tumor size and a positive rate for vessel involvement both in C-HCC and nBnC-HCC patients were larger and higher, respectively, in anti-HBc-positive patients compared with anti-HBc-negative patients, although the difference in nBnC-HCC did not reach statistical significance because of the small numbers. These tumor characteristics were similar to those of B-HCC patients. Conclusion: A possible contribution of prior HBV infection to the development of HCC is indicated.",
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AU - Tanaka, Hironori

AU - Iwasaki, Yoshiaki

AU - Nouso, Kazuhiro

AU - Kobayashi, Yoshiyuki

AU - Nakamura, Shin Ichiro

AU - Matsumoto, Eiji

AU - Toshikuni, Nobuyuki

AU - Kaneyoshi, Toshihiko

AU - Ohsawa, Toshiya

AU - Takaguchi, Kouichi

AU - Fujio, Kozo

AU - Senoh, Tomonori

AU - Ohnishi, Tohru

AU - Sakaguchi, Kohsaku

AU - Shiratori, Yasushi

PY - 2005

Y1 - 2005

N2 - Background: The prevalence of prior hepatitis B virus (HBV) infection in hepatocellular carcinoma (HCC) patients and its role in hepatocarcinogenesis are not clear. The aim of the present study is to clarify the importance of prior HBV infection in development of HCC. Methods: Of 1288 consecutive HCC patients between January 1999 and October 2002, 1008 patients were enrolled. To determine the influence of prior HBV infection in hepatitis B surface antigen (HBsAg)-negative HCC, the prevalence of antibody to hepatitis B core antigen (anti-HBc) was examined according to age, and the clinical features were compared between the anti-HBc positive and the negative groups. Results: The proportion of HBsAg-negative HCC patients, HCC patients with antibody to hepatitis C virus (anti-HCV; C-HCC) and HCC patients negative for both HBsAg and anti-HCV (nBnC-HCC), increased with age. The anti-HBc-positive rates in C-HCC patients also increased with age. Those rates in nBnC-HCC patients were >50% in all age groups. Furthermore, it was found that the anti-HBc-positive rates of these patients were higher than those of corresponding control patients. Tumor size and a positive rate for vessel involvement both in C-HCC and nBnC-HCC patients were larger and higher, respectively, in anti-HBc-positive patients compared with anti-HBc-negative patients, although the difference in nBnC-HCC did not reach statistical significance because of the small numbers. These tumor characteristics were similar to those of B-HCC patients. Conclusion: A possible contribution of prior HBV infection to the development of HCC is indicated.

AB - Background: The prevalence of prior hepatitis B virus (HBV) infection in hepatocellular carcinoma (HCC) patients and its role in hepatocarcinogenesis are not clear. The aim of the present study is to clarify the importance of prior HBV infection in development of HCC. Methods: Of 1288 consecutive HCC patients between January 1999 and October 2002, 1008 patients were enrolled. To determine the influence of prior HBV infection in hepatitis B surface antigen (HBsAg)-negative HCC, the prevalence of antibody to hepatitis B core antigen (anti-HBc) was examined according to age, and the clinical features were compared between the anti-HBc positive and the negative groups. Results: The proportion of HBsAg-negative HCC patients, HCC patients with antibody to hepatitis C virus (anti-HCV; C-HCC) and HCC patients negative for both HBsAg and anti-HCV (nBnC-HCC), increased with age. The anti-HBc-positive rates in C-HCC patients also increased with age. Those rates in nBnC-HCC patients were >50% in all age groups. Furthermore, it was found that the anti-HBc-positive rates of these patients were higher than those of corresponding control patients. Tumor size and a positive rate for vessel involvement both in C-HCC and nBnC-HCC patients were larger and higher, respectively, in anti-HBc-positive patients compared with anti-HBc-negative patients, although the difference in nBnC-HCC did not reach statistical significance because of the small numbers. These tumor characteristics were similar to those of B-HCC patients. Conclusion: A possible contribution of prior HBV infection to the development of HCC is indicated.

KW - Antibody to hepatitis B core antigen

KW - Hepatitis B

KW - Hepatocellular carcinoma

KW - Occult HBV infection

KW - Prior HBV infection

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