Possible Anti-tumor Promoting Properties of Edible Plants from Thailand, and Identification of an Active Constituent, Cardamonin, of Boesenbergia pandurata

Akira Murakami; Akira Kondo; Yoshimasa Nakamura; Hajime Ohigashi; Koichi Koshimizu

doi:10.1271/bbb.57.1971

Possible Anti-tumor Promoting Properties of Edible Plants from Thailand, and Identification of an Active Constituent, Cardamonin, of Boesenbergia pandurata

Akira Murakami, Akira Kondo, Yoshimasa Nakamura, Hajime Ohigashi, Koichi Koshimizu

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

Possible anti-tumor promoting properties of a total of 40 methanol extracts from Thai edible plants, including 5 non-edible species, were estimated in vitro by an inhibition test of tumor promoter-induced Epstein-Barr virus (EBV) activation. Fourteen species (35% of the total) were found to be strongly active. In addition, cardamonin (2′,4′-dihydroxy-6′-methoxychalcone) was identified as a potently active constituent (IC₅₀ = 3.1 μm) of Boesenbergia pandurata (Zingiberaceae), suggesting it to be an effective anti-tumor promoter.

Original language	English
Pages (from-to)	1971-1973
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	57
Issue number	11
DOIs	https://doi.org/10.1271/bbb.57.1971
Publication status	Published - 1993
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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abstract = "Possible anti-tumor promoting properties of a total of 40 methanol extracts from Thai edible plants, including 5 non-edible species, were estimated in vitro by an inhibition test of tumor promoter-induced Epstein-Barr virus (EBV) activation. Fourteen species (35% of the total) were found to be strongly active. In addition, cardamonin (2′,4′-dihydroxy-6′-methoxychalcone) was identified as a potently active constituent (IC50 = 3.1 μm) of Boesenbergia pandurata (Zingiberaceae), suggesting it to be an effective anti-tumor promoter.",

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AU - Nakamura, Yoshimasa

AU - Ohigashi, Hajime

AU - Koshimizu, Koichi

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AB - Possible anti-tumor promoting properties of a total of 40 methanol extracts from Thai edible plants, including 5 non-edible species, were estimated in vitro by an inhibition test of tumor promoter-induced Epstein-Barr virus (EBV) activation. Fourteen species (35% of the total) were found to be strongly active. In addition, cardamonin (2′,4′-dihydroxy-6′-methoxychalcone) was identified as a potently active constituent (IC50 = 3.1 μm) of Boesenbergia pandurata (Zingiberaceae), suggesting it to be an effective anti-tumor promoter.

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Possible Anti-tumor Promoting Properties of Edible Plants from Thailand, and Identification of an Active Constituent, Cardamonin, of Boesenbergia pandurata

Abstract

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