Possible absence of common polymorphisms in coagulation factor IX gene in Japanese subjects

T. Kojima, M. Tanimoto, T. Kamiya, Y. Obata, T. Takahashi, R. Ohno, K. Kurachi, H. Saito

Research output: Contribution to journalArticle

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Abstract

Four distinct intragenic polymorphisms in the coagulation factor IX gene which have been reported to be important for family diagnosis of Caucasian hemophilia B were studied in 51 normal Japanese subjects (21 males and 30 females). High-molecular-weight DNA prepared from peripheral blood lymphocytes were digested with endonuclease, DdeI, MspI, TaqI or XmnI, and were studied by Southern blot analysis with factor IX complementary DNA as a probe. None of the minor fragments produced by these enzymes was found in the normal Japanese DNA samples tested, although the probe detects minor allelic forms in control Caucasian DNA samples. Our data suggest that the frequent polymorphic sites found in Caucasians are possibly absent in the Japanese population.

Original languageEnglish
Pages (from-to)349-352
Number of pages4
JournalBlood
Volume69
Issue number1
Publication statusPublished - 1987
Externally publishedYes

Fingerprint

Factor IX
Polymorphism
Genes
Deoxyribonuclease HpaII
DNA
Hemophilia B
Lymphocytes
Southern Blotting
Blood
Complementary DNA
Molecular Weight
Molecular weight
Enzymes
Population

ASJC Scopus subject areas

  • Hematology

Cite this

Kojima, T., Tanimoto, M., Kamiya, T., Obata, Y., Takahashi, T., Ohno, R., ... Saito, H. (1987). Possible absence of common polymorphisms in coagulation factor IX gene in Japanese subjects. Blood, 69(1), 349-352.

Possible absence of common polymorphisms in coagulation factor IX gene in Japanese subjects. / Kojima, T.; Tanimoto, M.; Kamiya, T.; Obata, Y.; Takahashi, T.; Ohno, R.; Kurachi, K.; Saito, H.

In: Blood, Vol. 69, No. 1, 1987, p. 349-352.

Research output: Contribution to journalArticle

Kojima, T, Tanimoto, M, Kamiya, T, Obata, Y, Takahashi, T, Ohno, R, Kurachi, K & Saito, H 1987, 'Possible absence of common polymorphisms in coagulation factor IX gene in Japanese subjects', Blood, vol. 69, no. 1, pp. 349-352.
Kojima T, Tanimoto M, Kamiya T, Obata Y, Takahashi T, Ohno R et al. Possible absence of common polymorphisms in coagulation factor IX gene in Japanese subjects. Blood. 1987;69(1):349-352.
Kojima, T. ; Tanimoto, M. ; Kamiya, T. ; Obata, Y. ; Takahashi, T. ; Ohno, R. ; Kurachi, K. ; Saito, H. / Possible absence of common polymorphisms in coagulation factor IX gene in Japanese subjects. In: Blood. 1987 ; Vol. 69, No. 1. pp. 349-352.
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