Positive minimal residual disease of FLT3-ITD before hematopoietic stem cell transplantation resulted in a poor prognosis of an acute myeloid leukemia

Yuka Iwasaki; Rituo Nishiuchi; Michinori Aoe; Takahide Takahashi; Hirokazu Watanabe; Chiho Tokorotani; Kiyoshi Kikkawa; Akira Shimada

Positive minimal residual disease of FLT3-ITD before hematopoietic stem cell transplantation resulted in a poor prognosis of an acute myeloid leukemia

Yuka Iwasaki, Rituo Nishiuchi, Michinori Aoe, Takahide Takahashi, Hirokazu Watanabe, Chiho Tokorotani, Kiyoshi Kikkawa, Akira Shimada

University Hospital

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Acute myeloid leukemia (AML) patients with fms-related tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) often have a poor prognosis, even after hematopoietic stem cell transplantation (HSCT). We report a case of AML with FLT3-ITD identified upon initial diagnosis, who received HSCT at complete remission after 3 consecutive chemotherapies. However, the patient relapsed when the same FLT3-ITD clone emerged, and finally died. Retrospective analysis revealed an allelic ratio of FLT3-ITD/wild type of 1.1 and 0.0096 upon initial diagnosis and before HSCT, respectively. The detection of any minimal residual FLT3-ITD clone before HSCT is useful in the treatment of AML with FLT3-ITD.

Original language	English
Pages (from-to)	79-83
Number of pages	5
Journal	Acta medica Okayama
Volume	71
Issue number	1
Publication status	Published - 2017

Keywords

Acute myeloid leukemia
FLT3-ITD
HSCT
Minimal residual disease
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ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

Positive minimal residual disease of FLT3-ITD before hematopoietic stem cell transplantation resulted in a poor prognosis of an acute myeloid leukemia. / Iwasaki, Yuka; Nishiuchi, Rituo; Aoe, Michinori; Takahashi, Takahide; Watanabe, Hirokazu; Tokorotani, Chiho; Kikkawa, Kiyoshi; Shimada, Akira.

In: Acta medica Okayama, Vol. 71, No. 1, 2017, p. 79-83.

Research output: Contribution to journal › Article › peer-review

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title = "Positive minimal residual disease of FLT3-ITD before hematopoietic stem cell transplantation resulted in a poor prognosis of an acute myeloid leukemia",

abstract = "Acute myeloid leukemia (AML) patients with fms-related tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) often have a poor prognosis, even after hematopoietic stem cell transplantation (HSCT). We report a case of AML with FLT3-ITD identified upon initial diagnosis, who received HSCT at complete remission after 3 consecutive chemotherapies. However, the patient relapsed when the same FLT3-ITD clone emerged, and finally died. Retrospective analysis revealed an allelic ratio of FLT3-ITD/wild type of 1.1 and 0.0096 upon initial diagnosis and before HSCT, respectively. The detection of any minimal residual FLT3-ITD clone before HSCT is useful in the treatment of AML with FLT3-ITD.",

keywords = "Acute myeloid leukemia, FLT3-ITD, HSCT, Minimal residual disease, Relapse",

author = "Yuka Iwasaki and Rituo Nishiuchi and Michinori Aoe and Takahide Takahashi and Hirokazu Watanabe and Chiho Tokorotani and Kiyoshi Kikkawa and Akira Shimada",

note = "Funding Information: Acknowledgment.　Supported in part by a Grant-in-Aid for Cancer Research and a grant for Clinical Cancer Research and Research on Children and Families from the Ministry of Health, Labor and Welfare of Japan. Publisher Copyright: {\textcopyright} 2017 by Okayama University Medical School.",

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T1 - Positive minimal residual disease of FLT3-ITD before hematopoietic stem cell transplantation resulted in a poor prognosis of an acute myeloid leukemia

AU - Iwasaki, Yuka

AU - Nishiuchi, Rituo

AU - Aoe, Michinori

AU - Takahashi, Takahide

AU - Watanabe, Hirokazu

AU - Tokorotani, Chiho

AU - Kikkawa, Kiyoshi

AU - Shimada, Akira

N1 - Funding Information: Acknowledgment.　Supported in part by a Grant-in-Aid for Cancer Research and a grant for Clinical Cancer Research and Research on Children and Families from the Ministry of Health, Labor and Welfare of Japan. Publisher Copyright: © 2017 by Okayama University Medical School.

PY - 2017

Y1 - 2017

N2 - Acute myeloid leukemia (AML) patients with fms-related tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) often have a poor prognosis, even after hematopoietic stem cell transplantation (HSCT). We report a case of AML with FLT3-ITD identified upon initial diagnosis, who received HSCT at complete remission after 3 consecutive chemotherapies. However, the patient relapsed when the same FLT3-ITD clone emerged, and finally died. Retrospective analysis revealed an allelic ratio of FLT3-ITD/wild type of 1.1 and 0.0096 upon initial diagnosis and before HSCT, respectively. The detection of any minimal residual FLT3-ITD clone before HSCT is useful in the treatment of AML with FLT3-ITD.

AB - Acute myeloid leukemia (AML) patients with fms-related tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) often have a poor prognosis, even after hematopoietic stem cell transplantation (HSCT). We report a case of AML with FLT3-ITD identified upon initial diagnosis, who received HSCT at complete remission after 3 consecutive chemotherapies. However, the patient relapsed when the same FLT3-ITD clone emerged, and finally died. Retrospective analysis revealed an allelic ratio of FLT3-ITD/wild type of 1.1 and 0.0096 upon initial diagnosis and before HSCT, respectively. The detection of any minimal residual FLT3-ITD clone before HSCT is useful in the treatment of AML with FLT3-ITD.

KW - Acute myeloid leukemia

KW - FLT3-ITD

KW - HSCT

KW - Minimal residual disease

KW - Relapse

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Positive minimal residual disease of FLT3-ITD before hematopoietic stem cell transplantation resulted in a poor prognosis of an acute myeloid leukemia

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Keywords

ASJC Scopus subject areas

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