Porphyrins as potential inhibitors against exposure to carcinogens and mutagens

Hikoya Hayatsu, Tomoe Negishi, Sakae Arimoto, Toshiko Hayatsu

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Studies have shown that there are many substances that can interfere with the actions of carcinogens and mutagens. Porphyrins, which often are constituents of diet, are a class of such inhibitors. Hemin can inhibit selectively the activity of mutagens having polycyclic structures by forming complexes with them. These effects were found with the use of bacterial assays and also by in vitro chemical experiments. A survey of porphyrins for similar effects has been done in our laboratory and it was found that chlorophyll and chlorophyllin act like hemin. These green pigments are antimutagenic in Salmonella and in Drosophila. Work from other laboratories also has supported the antimutagenic character of chlorophyllin. The possibility of modifying human exposure to carcinogens by use of these porphyrins is discussed. A porphyrin-like molecule, copper phthalocyanine trisulfonate, has been shown to have strong affinity to polycyclic compounds. Blue cotton, a cotton preparation bearing this blue pigment as a covalently bound ligand, has been demonstrated to be an adsorbent useful for isolating heterocyclic amines from food and other materials.

Original languageEnglish
Pages (from-to)79-85
Number of pages7
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume290
Issue number1
DOIs
Publication statusPublished - 1993

Fingerprint

Porphyrins
Mutagens
Carcinogens
Hemin
Polycyclic Compounds
Chlorophyll
Salmonella
Drosophila
Amines
Diet
Ligands
Food
chlorophyllin

Keywords

  • Antimutagenic activity
  • Blue cotton
  • Blue rayon
  • Chlorophyll
  • Chlorophyllin
  • Hemin

ASJC Scopus subject areas

  • Molecular Biology
  • Health, Toxicology and Mutagenesis

Cite this

Porphyrins as potential inhibitors against exposure to carcinogens and mutagens. / Hayatsu, Hikoya; Negishi, Tomoe; Arimoto, Sakae; Hayatsu, Toshiko.

In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 290, No. 1, 1993, p. 79-85.

Research output: Contribution to journalArticle

@article{16e29de6dc51448c99def35d9ce8e9c0,
title = "Porphyrins as potential inhibitors against exposure to carcinogens and mutagens",
abstract = "Studies have shown that there are many substances that can interfere with the actions of carcinogens and mutagens. Porphyrins, which often are constituents of diet, are a class of such inhibitors. Hemin can inhibit selectively the activity of mutagens having polycyclic structures by forming complexes with them. These effects were found with the use of bacterial assays and also by in vitro chemical experiments. A survey of porphyrins for similar effects has been done in our laboratory and it was found that chlorophyll and chlorophyllin act like hemin. These green pigments are antimutagenic in Salmonella and in Drosophila. Work from other laboratories also has supported the antimutagenic character of chlorophyllin. The possibility of modifying human exposure to carcinogens by use of these porphyrins is discussed. A porphyrin-like molecule, copper phthalocyanine trisulfonate, has been shown to have strong affinity to polycyclic compounds. Blue cotton, a cotton preparation bearing this blue pigment as a covalently bound ligand, has been demonstrated to be an adsorbent useful for isolating heterocyclic amines from food and other materials.",
keywords = "Antimutagenic activity, Blue cotton, Blue rayon, Chlorophyll, Chlorophyllin, Hemin",
author = "Hikoya Hayatsu and Tomoe Negishi and Sakae Arimoto and Toshiko Hayatsu",
year = "1993",
doi = "10.1016/0027-5107(93)90035-E",
language = "English",
volume = "290",
pages = "79--85",
journal = "Mutation Research",
issn = "0027-5107",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Porphyrins as potential inhibitors against exposure to carcinogens and mutagens

AU - Hayatsu, Hikoya

AU - Negishi, Tomoe

AU - Arimoto, Sakae

AU - Hayatsu, Toshiko

PY - 1993

Y1 - 1993

N2 - Studies have shown that there are many substances that can interfere with the actions of carcinogens and mutagens. Porphyrins, which often are constituents of diet, are a class of such inhibitors. Hemin can inhibit selectively the activity of mutagens having polycyclic structures by forming complexes with them. These effects were found with the use of bacterial assays and also by in vitro chemical experiments. A survey of porphyrins for similar effects has been done in our laboratory and it was found that chlorophyll and chlorophyllin act like hemin. These green pigments are antimutagenic in Salmonella and in Drosophila. Work from other laboratories also has supported the antimutagenic character of chlorophyllin. The possibility of modifying human exposure to carcinogens by use of these porphyrins is discussed. A porphyrin-like molecule, copper phthalocyanine trisulfonate, has been shown to have strong affinity to polycyclic compounds. Blue cotton, a cotton preparation bearing this blue pigment as a covalently bound ligand, has been demonstrated to be an adsorbent useful for isolating heterocyclic amines from food and other materials.

AB - Studies have shown that there are many substances that can interfere with the actions of carcinogens and mutagens. Porphyrins, which often are constituents of diet, are a class of such inhibitors. Hemin can inhibit selectively the activity of mutagens having polycyclic structures by forming complexes with them. These effects were found with the use of bacterial assays and also by in vitro chemical experiments. A survey of porphyrins for similar effects has been done in our laboratory and it was found that chlorophyll and chlorophyllin act like hemin. These green pigments are antimutagenic in Salmonella and in Drosophila. Work from other laboratories also has supported the antimutagenic character of chlorophyllin. The possibility of modifying human exposure to carcinogens by use of these porphyrins is discussed. A porphyrin-like molecule, copper phthalocyanine trisulfonate, has been shown to have strong affinity to polycyclic compounds. Blue cotton, a cotton preparation bearing this blue pigment as a covalently bound ligand, has been demonstrated to be an adsorbent useful for isolating heterocyclic amines from food and other materials.

KW - Antimutagenic activity

KW - Blue cotton

KW - Blue rayon

KW - Chlorophyll

KW - Chlorophyllin

KW - Hemin

UR - http://www.scopus.com/inward/record.url?scp=0027370522&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027370522&partnerID=8YFLogxK

U2 - 10.1016/0027-5107(93)90035-E

DO - 10.1016/0027-5107(93)90035-E

M3 - Article

C2 - 7694102

AN - SCOPUS:0027370522

VL - 290

SP - 79

EP - 85

JO - Mutation Research

JF - Mutation Research

SN - 0027-5107

IS - 1

ER -