Abstract
Responses of peripheral blood mononuclear cells to synthetic oligopeptides of Der p II, one of the major allergen molecules of Dermatophagoides pteronyssinus, were compared between allergic and nonallergic subjects. Healthy subjects showed positive responses to crude extracts of D. pteronyssinus, but only allergic subjects showed elevated cellular responses to Der p II. We synthesized three oligopeptides of Der p II in which motifs of a possible T-cell epitope were included. Of 14 subjects with positive response to Der p II, three responded to all three peptides, while five did not respond to any peptide tested. In 11 allergic patients who showed positive response to Der p II, responsiveness to the peptide K33-T47 was significantly higher than that to other peptides (P
| Original language | English |
|---|---|
| Pages (from-to) | 436-441 |
| Number of pages | 6 |
| Journal | Allergy: European Journal of Allergy and Clinical Immunology |
| Volume | 49 |
| Issue number | 6 |
| Publication status | Published - 1994 |
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Keywords
- Der p II
- Dermatophagoides spp
- House-dust mite allergy
- Human T cells
- Synthetic peptides
- T epitope
ASJC Scopus subject areas
- Immunology
Cite this
Population analysis of cellular responses to synthetic peptides of Der p II, a major allergen molecule of Dermatophagoides pteronyssinus, in allergic and nonallergic subjects. / Okano, M.; Nagano, T.; Kino, K.; Yasueda, H.; Baba, Y.; Saito, C.; Masuda, Y.; Ohta, N.
In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 49, No. 6, 1994, p. 436-441.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Population analysis of cellular responses to synthetic peptides of Der p II, a major allergen molecule of Dermatophagoides pteronyssinus, in allergic and nonallergic subjects
AU - Okano, M.
AU - Nagano, T.
AU - Kino, K.
AU - Yasueda, H.
AU - Baba, Y.
AU - Saito, C.
AU - Masuda, Y.
AU - Ohta, N.
PY - 1994
Y1 - 1994
N2 - Responses of peripheral blood mononuclear cells to synthetic oligopeptides of Der p II, one of the major allergen molecules of Dermatophagoides pteronyssinus, were compared between allergic and nonallergic subjects. Healthy subjects showed positive responses to crude extracts of D. pteronyssinus, but only allergic subjects showed elevated cellular responses to Der p II. We synthesized three oligopeptides of Der p II in which motifs of a possible T-cell epitope were included. Of 14 subjects with positive response to Der p II, three responded to all three peptides, while five did not respond to any peptide tested. In 11 allergic patients who showed positive response to Der p II, responsiveness to the peptide K33-T47 was significantly higher than that to other peptides (P
AB - Responses of peripheral blood mononuclear cells to synthetic oligopeptides of Der p II, one of the major allergen molecules of Dermatophagoides pteronyssinus, were compared between allergic and nonallergic subjects. Healthy subjects showed positive responses to crude extracts of D. pteronyssinus, but only allergic subjects showed elevated cellular responses to Der p II. We synthesized three oligopeptides of Der p II in which motifs of a possible T-cell epitope were included. Of 14 subjects with positive response to Der p II, three responded to all three peptides, while five did not respond to any peptide tested. In 11 allergic patients who showed positive response to Der p II, responsiveness to the peptide K33-T47 was significantly higher than that to other peptides (P
KW - Der p II
KW - Dermatophagoides spp
KW - House-dust mite allergy
KW - Human T cells
KW - Synthetic peptides
KW - T epitope
UR - http://www.scopus.com/inward/record.url?scp=0028243998&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028243998&partnerID=8YFLogxK
M3 - Article
C2 - 7521142
AN - SCOPUS:0028243998
VL - 49
SP - 436
EP - 441
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
SN - 0105-4538
IS - 6
ER -