Polymorphisms of estrogen metabolism-related genes ESR1, UGT2B17, and UGT1A1 are not associated with osteoporosis in surgically menopausal Japanese women

Megumi Yokota, Akira Hirasawa, Kazuya Makita, Tomoko Akahane, Kensuke Sakai, Takeshi Makabe, Yuko Horiba, Wataru Yamagami, Mariko Ogawa, Takashi Iwata, Shigehisa Yanamoto, Ryota Deshimaru, Kouji Banno, Nobuyuki Susumu, Daisuke Aoki

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Introduction: Bilateral salpingo-oophorectomy (BSO) is a risk factor for osteoporosis. Previous studies have reported an association between genetic polymorphisms and the risk of developing osteoporosis. However, the relationship between osteoporosis and genetic polymorphisms in Japanese women treated with BSO is not well understood. To improve the quality of life for post-BSO patients, it is important to determine the genetic factors that influence their risk for osteoporosis. The aim of this study was to investigate the association between gene variations of estrogen metabolism-related genes and osteoporosis in surgically menopausal patients, which may improve their quality of life. Material and methods: This study included 203 menopausal women treated with BSO because of gynecologic disorders. One hundred and twenty-six women with artificial (surgical) menopause, who had undergone BSO in the premenopausal period, were compared with 77 women with natural menopause, who had undergone BSO in the postmenopausal period. The women were tested for bone mineral density to diagnose osteoporosis. Polymorphisms of estrogen receptor 1 (ESR1) and UDP-glucuronosyl transferase (UGT) genes UGT2B17 and UGT1A1 were analyzed, and their association with bone mass and osteoporosis was statistically evaluated. Results: No significant association was found between osteoporosis and polymorphisms in ESR1, UGT2B17, or UGT1A1 in both groups, suggesting that BSO might be a more significant physiological factor in influencing bone mass density compared to genetic variations. Conclusions: These results suggest that the ESR1, UGT2B17, and UGT1A1 polymorphisms are not genetic factors affecting osteoporosis in postmenopausal Japanese women.

Original languageEnglish
Pages (from-to)161-167
Number of pages7
JournalPrzeglad Menopauzalny
Volume14
Issue number3
DOIs
Publication statusPublished - Jan 1 2015
Externally publishedYes

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Ovariectomy
Osteoporosis
Estrogens
Genes
Estrogen Receptor alpha
Genetic Polymorphisms
Menopause
Bone Density
Premenopause
Quality of Life
Postmenopause
Postmenopausal Osteoporosis
Uridine Diphosphate
ERRalpha estrogen-related receptor
Transferases
Bone and Bones

Keywords

  • Bilateral salpingo-oophorectomy
  • Bone mineral density
  • Gene polymorphism
  • Menopause
  • Osteoporosis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Obstetrics and Gynaecology

Cite this

Polymorphisms of estrogen metabolism-related genes ESR1, UGT2B17, and UGT1A1 are not associated with osteoporosis in surgically menopausal Japanese women. / Yokota, Megumi; Hirasawa, Akira; Makita, Kazuya; Akahane, Tomoko; Sakai, Kensuke; Makabe, Takeshi; Horiba, Yuko; Yamagami, Wataru; Ogawa, Mariko; Iwata, Takashi; Yanamoto, Shigehisa; Deshimaru, Ryota; Banno, Kouji; Susumu, Nobuyuki; Aoki, Daisuke.

In: Przeglad Menopauzalny, Vol. 14, No. 3, 01.01.2015, p. 161-167.

Research output: Contribution to journalArticle

Yokota, M, Hirasawa, A, Makita, K, Akahane, T, Sakai, K, Makabe, T, Horiba, Y, Yamagami, W, Ogawa, M, Iwata, T, Yanamoto, S, Deshimaru, R, Banno, K, Susumu, N & Aoki, D 2015, 'Polymorphisms of estrogen metabolism-related genes ESR1, UGT2B17, and UGT1A1 are not associated with osteoporosis in surgically menopausal Japanese women', Przeglad Menopauzalny, vol. 14, no. 3, pp. 161-167. https://doi.org/10.5114/pm.2015.54339
Yokota, Megumi ; Hirasawa, Akira ; Makita, Kazuya ; Akahane, Tomoko ; Sakai, Kensuke ; Makabe, Takeshi ; Horiba, Yuko ; Yamagami, Wataru ; Ogawa, Mariko ; Iwata, Takashi ; Yanamoto, Shigehisa ; Deshimaru, Ryota ; Banno, Kouji ; Susumu, Nobuyuki ; Aoki, Daisuke. / Polymorphisms of estrogen metabolism-related genes ESR1, UGT2B17, and UGT1A1 are not associated with osteoporosis in surgically menopausal Japanese women. In: Przeglad Menopauzalny. 2015 ; Vol. 14, No. 3. pp. 161-167.
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abstract = "Introduction: Bilateral salpingo-oophorectomy (BSO) is a risk factor for osteoporosis. Previous studies have reported an association between genetic polymorphisms and the risk of developing osteoporosis. However, the relationship between osteoporosis and genetic polymorphisms in Japanese women treated with BSO is not well understood. To improve the quality of life for post-BSO patients, it is important to determine the genetic factors that influence their risk for osteoporosis. The aim of this study was to investigate the association between gene variations of estrogen metabolism-related genes and osteoporosis in surgically menopausal patients, which may improve their quality of life. Material and methods: This study included 203 menopausal women treated with BSO because of gynecologic disorders. One hundred and twenty-six women with artificial (surgical) menopause, who had undergone BSO in the premenopausal period, were compared with 77 women with natural menopause, who had undergone BSO in the postmenopausal period. The women were tested for bone mineral density to diagnose osteoporosis. Polymorphisms of estrogen receptor 1 (ESR1) and UDP-glucuronosyl transferase (UGT) genes UGT2B17 and UGT1A1 were analyzed, and their association with bone mass and osteoporosis was statistically evaluated. Results: No significant association was found between osteoporosis and polymorphisms in ESR1, UGT2B17, or UGT1A1 in both groups, suggesting that BSO might be a more significant physiological factor in influencing bone mass density compared to genetic variations. Conclusions: These results suggest that the ESR1, UGT2B17, and UGT1A1 polymorphisms are not genetic factors affecting osteoporosis in postmenopausal Japanese women.",
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T1 - Polymorphisms of estrogen metabolism-related genes ESR1, UGT2B17, and UGT1A1 are not associated with osteoporosis in surgically menopausal Japanese women

AU - Yokota, Megumi

AU - Hirasawa, Akira

AU - Makita, Kazuya

AU - Akahane, Tomoko

AU - Sakai, Kensuke

AU - Makabe, Takeshi

AU - Horiba, Yuko

AU - Yamagami, Wataru

AU - Ogawa, Mariko

AU - Iwata, Takashi

AU - Yanamoto, Shigehisa

AU - Deshimaru, Ryota

AU - Banno, Kouji

AU - Susumu, Nobuyuki

AU - Aoki, Daisuke

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Introduction: Bilateral salpingo-oophorectomy (BSO) is a risk factor for osteoporosis. Previous studies have reported an association between genetic polymorphisms and the risk of developing osteoporosis. However, the relationship between osteoporosis and genetic polymorphisms in Japanese women treated with BSO is not well understood. To improve the quality of life for post-BSO patients, it is important to determine the genetic factors that influence their risk for osteoporosis. The aim of this study was to investigate the association between gene variations of estrogen metabolism-related genes and osteoporosis in surgically menopausal patients, which may improve their quality of life. Material and methods: This study included 203 menopausal women treated with BSO because of gynecologic disorders. One hundred and twenty-six women with artificial (surgical) menopause, who had undergone BSO in the premenopausal period, were compared with 77 women with natural menopause, who had undergone BSO in the postmenopausal period. The women were tested for bone mineral density to diagnose osteoporosis. Polymorphisms of estrogen receptor 1 (ESR1) and UDP-glucuronosyl transferase (UGT) genes UGT2B17 and UGT1A1 were analyzed, and their association with bone mass and osteoporosis was statistically evaluated. Results: No significant association was found between osteoporosis and polymorphisms in ESR1, UGT2B17, or UGT1A1 in both groups, suggesting that BSO might be a more significant physiological factor in influencing bone mass density compared to genetic variations. Conclusions: These results suggest that the ESR1, UGT2B17, and UGT1A1 polymorphisms are not genetic factors affecting osteoporosis in postmenopausal Japanese women.

AB - Introduction: Bilateral salpingo-oophorectomy (BSO) is a risk factor for osteoporosis. Previous studies have reported an association between genetic polymorphisms and the risk of developing osteoporosis. However, the relationship between osteoporosis and genetic polymorphisms in Japanese women treated with BSO is not well understood. To improve the quality of life for post-BSO patients, it is important to determine the genetic factors that influence their risk for osteoporosis. The aim of this study was to investigate the association between gene variations of estrogen metabolism-related genes and osteoporosis in surgically menopausal patients, which may improve their quality of life. Material and methods: This study included 203 menopausal women treated with BSO because of gynecologic disorders. One hundred and twenty-six women with artificial (surgical) menopause, who had undergone BSO in the premenopausal period, were compared with 77 women with natural menopause, who had undergone BSO in the postmenopausal period. The women were tested for bone mineral density to diagnose osteoporosis. Polymorphisms of estrogen receptor 1 (ESR1) and UDP-glucuronosyl transferase (UGT) genes UGT2B17 and UGT1A1 were analyzed, and their association with bone mass and osteoporosis was statistically evaluated. Results: No significant association was found between osteoporosis and polymorphisms in ESR1, UGT2B17, or UGT1A1 in both groups, suggesting that BSO might be a more significant physiological factor in influencing bone mass density compared to genetic variations. Conclusions: These results suggest that the ESR1, UGT2B17, and UGT1A1 polymorphisms are not genetic factors affecting osteoporosis in postmenopausal Japanese women.

KW - Bilateral salpingo-oophorectomy

KW - Bone mineral density

KW - Gene polymorphism

KW - Menopause

KW - Osteoporosis

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DO - 10.5114/pm.2015.54339

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