Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population

Kikuko Hotta, Michihiro Nakamura, Takahiro Nakamura, Tomoaki Matsuo, Yoshio Nakata, Seika Kamohara, Nobuyuki Miyatake, Kazuaki Kotani, Ryoya Komatsu, Naoto Itoh, Ikuo Mineo, Jun Wada, Masato Yoneda, Atsushi Nakajima, Tohru Funahashi, Shigeru Miyazaki, Katsuto Tokunaga, Manabu Kawamoto, Hiroaki Masuzaki, Takato Ueno & 11 others Kazuyuki Hamaguchi, Kiyoji Tanaka, Kentaro Yamada, Toshiaki Hanafusa, Shinichi Oikawa, Hironobu Yoshimatsu, Kazuwa Nakao, Toshiie Sakata, Yuji Matsuzawa, Yusuke Nakamura, Naoyuki Kamatani

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The predominant risk factor of metabolic syndrome is intra-abdominal fat accumulation, which is determined by waist circumference and waist-hip ratio measurements and visceral fat area (VFA) that is measured by computed tomography (CT). There is evidence that waist circumference and waist-hip ratio in the Caucasian population are associated with variations in several genes, including neurexin 3 (NRXN3), transcription factor AP-2β (TFAP2B), methionine sulfoxide reductase A (MSRA), lysophospholipase-like-1 (LYPLAL1), fat mass and obesity associated (FTO) and melanocortin 4 receptor (MC4R) genes. To investigate the relationship between VFA and subcutaneous fat area (SFA) and these genes in the recruited Japanese population, we genotyped 8 single-nucleotide polymorphisms (SNPs) in these 6 genes from 1228 subjects. Multiple regression analysis revealed that gender, age, and rs1558902 and rs1421085 genotypes (additive model) in FTO were significantly associated with body mass index (BMI; P=0.0039 and 0.0039, respectively), SFA (P=0.0027 and 0.0023, respectively) and VFA (P=0.045 and 0.040, respectively). However, SNPs in other genes, namely, NRXN3, TFAP2B, MSRA, LYPLAL1 and MC4R were not significantly associated with BMI, SFA or VFA. Our data suggest that some SNPs, which were identified in genome-wide studies in the Caucasians, also confer susceptibility to fat distribution in the Japanese subjects.

Original languageEnglish
Pages (from-to)738-742
Number of pages5
JournalJournal of Human Genetics
Volume55
Issue number11
DOIs
Publication statusPublished - Nov 2010

Fingerprint

Methionine Sulfoxide Reductases
Lysophospholipase
Receptor, Melanocortin, Type 4
Intra-Abdominal Fat
Subcutaneous Fat
Single Nucleotide Polymorphism
Waist-Hip Ratio
Population
Genes
Waist Circumference
Transcription Factor AP-2
Fats
Body Mass Index
Obesity
Genotype
Tomography
Regression Analysis
Genome

Keywords

  • fat mass and obesity associated (FTO)
  • lysophospholipase-like 1 (LYPLAL1)
  • melanocortin 4 receptor (MC4R)
  • methionine sulfoxide reductase A (MSRA)
  • neurexin 3 (NRXN3)
  • subcutaneous fat area
  • transcription factor AP-2-β (TFAP2B)
  • visceral fat area

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Hotta, K., Nakamura, M., Nakamura, T., Matsuo, T., Nakata, Y., Kamohara, S., ... Kamatani, N. (2010). Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population. Journal of Human Genetics, 55(11), 738-742. https://doi.org/10.1038/jhg.2010.99

Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population. / Hotta, Kikuko; Nakamura, Michihiro; Nakamura, Takahiro; Matsuo, Tomoaki; Nakata, Yoshio; Kamohara, Seika; Miyatake, Nobuyuki; Kotani, Kazuaki; Komatsu, Ryoya; Itoh, Naoto; Mineo, Ikuo; Wada, Jun; Yoneda, Masato; Nakajima, Atsushi; Funahashi, Tohru; Miyazaki, Shigeru; Tokunaga, Katsuto; Kawamoto, Manabu; Masuzaki, Hiroaki; Ueno, Takato; Hamaguchi, Kazuyuki; Tanaka, Kiyoji; Yamada, Kentaro; Hanafusa, Toshiaki; Oikawa, Shinichi; Yoshimatsu, Hironobu; Nakao, Kazuwa; Sakata, Toshiie; Matsuzawa, Yuji; Nakamura, Yusuke; Kamatani, Naoyuki.

In: Journal of Human Genetics, Vol. 55, No. 11, 11.2010, p. 738-742.

Research output: Contribution to journalArticle

Hotta, K, Nakamura, M, Nakamura, T, Matsuo, T, Nakata, Y, Kamohara, S, Miyatake, N, Kotani, K, Komatsu, R, Itoh, N, Mineo, I, Wada, J, Yoneda, M, Nakajima, A, Funahashi, T, Miyazaki, S, Tokunaga, K, Kawamoto, M, Masuzaki, H, Ueno, T, Hamaguchi, K, Tanaka, K, Yamada, K, Hanafusa, T, Oikawa, S, Yoshimatsu, H, Nakao, K, Sakata, T, Matsuzawa, Y, Nakamura, Y & Kamatani, N 2010, 'Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population', Journal of Human Genetics, vol. 55, no. 11, pp. 738-742. https://doi.org/10.1038/jhg.2010.99
Hotta, Kikuko ; Nakamura, Michihiro ; Nakamura, Takahiro ; Matsuo, Tomoaki ; Nakata, Yoshio ; Kamohara, Seika ; Miyatake, Nobuyuki ; Kotani, Kazuaki ; Komatsu, Ryoya ; Itoh, Naoto ; Mineo, Ikuo ; Wada, Jun ; Yoneda, Masato ; Nakajima, Atsushi ; Funahashi, Tohru ; Miyazaki, Shigeru ; Tokunaga, Katsuto ; Kawamoto, Manabu ; Masuzaki, Hiroaki ; Ueno, Takato ; Hamaguchi, Kazuyuki ; Tanaka, Kiyoji ; Yamada, Kentaro ; Hanafusa, Toshiaki ; Oikawa, Shinichi ; Yoshimatsu, Hironobu ; Nakao, Kazuwa ; Sakata, Toshiie ; Matsuzawa, Yuji ; Nakamura, Yusuke ; Kamatani, Naoyuki. / Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population. In: Journal of Human Genetics. 2010 ; Vol. 55, No. 11. pp. 738-742.
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abstract = "The predominant risk factor of metabolic syndrome is intra-abdominal fat accumulation, which is determined by waist circumference and waist-hip ratio measurements and visceral fat area (VFA) that is measured by computed tomography (CT). There is evidence that waist circumference and waist-hip ratio in the Caucasian population are associated with variations in several genes, including neurexin 3 (NRXN3), transcription factor AP-2β (TFAP2B), methionine sulfoxide reductase A (MSRA), lysophospholipase-like-1 (LYPLAL1), fat mass and obesity associated (FTO) and melanocortin 4 receptor (MC4R) genes. To investigate the relationship between VFA and subcutaneous fat area (SFA) and these genes in the recruited Japanese population, we genotyped 8 single-nucleotide polymorphisms (SNPs) in these 6 genes from 1228 subjects. Multiple regression analysis revealed that gender, age, and rs1558902 and rs1421085 genotypes (additive model) in FTO were significantly associated with body mass index (BMI; P=0.0039 and 0.0039, respectively), SFA (P=0.0027 and 0.0023, respectively) and VFA (P=0.045 and 0.040, respectively). However, SNPs in other genes, namely, NRXN3, TFAP2B, MSRA, LYPLAL1 and MC4R were not significantly associated with BMI, SFA or VFA. Our data suggest that some SNPs, which were identified in genome-wide studies in the Caucasians, also confer susceptibility to fat distribution in the Japanese subjects.",
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author = "Kikuko Hotta and Michihiro Nakamura and Takahiro Nakamura and Tomoaki Matsuo and Yoshio Nakata and Seika Kamohara and Nobuyuki Miyatake and Kazuaki Kotani and Ryoya Komatsu and Naoto Itoh and Ikuo Mineo and Jun Wada and Masato Yoneda and Atsushi Nakajima and Tohru Funahashi and Shigeru Miyazaki and Katsuto Tokunaga and Manabu Kawamoto and Hiroaki Masuzaki and Takato Ueno and Kazuyuki Hamaguchi and Kiyoji Tanaka and Kentaro Yamada and Toshiaki Hanafusa and Shinichi Oikawa and Hironobu Yoshimatsu and Kazuwa Nakao and Toshiie Sakata and Yuji Matsuzawa and Yusuke Nakamura and Naoyuki Kamatani",
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AU - Nakata, Yoshio

AU - Kamohara, Seika

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AU - Ueno, Takato

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