Polymethylated γ-carbolines with potent anti-bovine viral diarrhea virus (BVDV) activity

Hiroshi Aoyama, Kumiko Sako, Shinichi Sato, Masahiko Nakamura, Hiroyuki Miyachi, Yukinori Goto, Mika Okamoto, Masanori Baba, Yuichi Hashimoto

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Several anti-BVDV agents with a polymethylated γ-carboline skeleton were synthesized, and their anti-BVDV activity was evaluated. The most potent antiviral agent, SK3M4M5M (20), was synthesized by Pd-catalyzed Buchwald-Hartwig amination reaction followed by annulation reaction as key steps. The structure-activity relationship was analyzed.

Original languageEnglish
Pages (from-to)779-785
Number of pages7
JournalHeterocycles
Volume77
Issue number2
DOIs
Publication statusPublished - Feb 1 2009

Keywords

  • Anti-BVDV Agent
  • Buchwald-Hartwig Amination
  • Palladium-Catalyzed
  • Quantitative Structure-Activity Relationship (QSAR)
  • γ-Carboline

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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  • Cite this

    Aoyama, H., Sako, K., Sato, S., Nakamura, M., Miyachi, H., Goto, Y., Okamoto, M., Baba, M., & Hashimoto, Y. (2009). Polymethylated γ-carbolines with potent anti-bovine viral diarrhea virus (BVDV) activity. Heterocycles, 77(2), 779-785. https://doi.org/10.3987/COM-08-S(F)68