Polymeric micelles incorporating (1,2-diaminocyclohexane)platinum (II) suppress the growth of orthotopic scirrhous gastric tumors and their lymph node metastasis

Md Rafi, H. Cabral, Mitsunobu Kano, P. Mi, C. Iwata, M. Yashiro, K. Hirakawa, K. Miyazono, N. Nishiyama, K. Kataoka

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Nano-scaled drug carriers have great potential for the treatment of solid tumors. Nevertheless, hypovascularity and fibrosis in some types of solid tumors have been demonstrated to reduce the penetration and accumulation of nano-scaled drug carriers. Diffuse-type scirrhous gastric cancers present such characteristics as well as frequent metastasis to the lymph nodes; therefore, it remains a great challenge to eradicate scirrhous gastric cancers based on the drug targeting using nanocarriers. Herein, we demonstrated that polymeric micelles with 30-nm diameter incorporating (1,2-diaminocyclohexane)platinum(II) (DACHPt), the parent complex of the anticancer drug oxaliplatin, efficiently penetrated and accumulated in an orthotopic scirrhous gastric cancer model, leading to the inhibition of the tumor growth. Moreover, the elevated localization of systemically injected DACHPt-loaded micelles in metastastic lymph nodes reduced the metastatic tumor growth. These results suggest DACHPt-loaded micelles as a promising nanocarrier for the treatment of scirrhous gastric cancers and their lymphatic metastases.

Original languageEnglish
Pages (from-to)189-196
Number of pages8
JournalJournal of Controlled Release
Volume159
Issue number2
DOIs
Publication statusPublished - Apr 30 2012
Externally publishedYes

Fingerprint

Micelles
Stomach Neoplasms
Stomach
Lymph Nodes
Neoplasm Metastasis
Drug Carriers
oxaliplatin
Growth
Platinum
Neoplasms
Lymphatic Metastasis
Drug Delivery Systems
Fibrosis
((1R,2R)-1,2-diaminocyclohexane)platinum(II)
Therapeutics
Pharmaceutical Preparations

Keywords

  • Chemotherapy
  • Drug delivery
  • Gastric cancer
  • Lymph node metastasis
  • Polymeric micelles

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Polymeric micelles incorporating (1,2-diaminocyclohexane)platinum (II) suppress the growth of orthotopic scirrhous gastric tumors and their lymph node metastasis. / Rafi, Md; Cabral, H.; Kano, Mitsunobu; Mi, P.; Iwata, C.; Yashiro, M.; Hirakawa, K.; Miyazono, K.; Nishiyama, N.; Kataoka, K.

In: Journal of Controlled Release, Vol. 159, No. 2, 30.04.2012, p. 189-196.

Research output: Contribution to journalArticle

Rafi, Md ; Cabral, H. ; Kano, Mitsunobu ; Mi, P. ; Iwata, C. ; Yashiro, M. ; Hirakawa, K. ; Miyazono, K. ; Nishiyama, N. ; Kataoka, K. / Polymeric micelles incorporating (1,2-diaminocyclohexane)platinum (II) suppress the growth of orthotopic scirrhous gastric tumors and their lymph node metastasis. In: Journal of Controlled Release. 2012 ; Vol. 159, No. 2. pp. 189-196.
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