TY - JOUR
T1 - Polymeric Materials, Advances and Applications in Tissue Engineering
T2 - A Review
AU - Socci, María Cecilia
AU - Rodríguez, Gabriela
AU - Oliva, Emilia
AU - Fushimi, Shigeko
AU - Takabatake, Kiyofumi
AU - Nagatsuka, Hitoshi
AU - Felice, Carmelo José
AU - Rodríguez, Andrea Paola
N1 - Funding Information:
This research was funded by JSPS KAKENHI Grant Numbers JP20H03888, JP20K10178, and JP19K19159.
Publisher Copyright:
© 2023 by the authors.
PY - 2023/2
Y1 - 2023/2
N2 - Tissue Engineering (TE) is an interdisciplinary field that encompasses materials science in combination with biological and engineering sciences. In recent years, an increase in the demand for therapeutic strategies for improving quality of life has necessitated innovative approaches to designing intelligent biomaterials aimed at the regeneration of tissues and organs. Polymeric porous scaffolds play a critical role in TE strategies for providing a favorable environment for tissue restoration and establishing the interaction of the biomaterial with cells and inducing substances. This article reviewed the various polymeric scaffold materials and their production techniques, as well as the basic elements and principles of TE. Several interesting strategies in eight main TE application areas of epithelial, bone, uterine, vascular, nerve, cartilaginous, cardiac, and urinary tissue were included with the aim of learning about current approaches in TE. Different polymer-based medical devices approved for use in clinical trials and a wide variety of polymeric biomaterials are currently available as commercial products. However, there still are obstacles that limit the clinical translation of TE implants for use wide in humans, and much research work is still needed in the field of regenerative medicine.
AB - Tissue Engineering (TE) is an interdisciplinary field that encompasses materials science in combination with biological and engineering sciences. In recent years, an increase in the demand for therapeutic strategies for improving quality of life has necessitated innovative approaches to designing intelligent biomaterials aimed at the regeneration of tissues and organs. Polymeric porous scaffolds play a critical role in TE strategies for providing a favorable environment for tissue restoration and establishing the interaction of the biomaterial with cells and inducing substances. This article reviewed the various polymeric scaffold materials and their production techniques, as well as the basic elements and principles of TE. Several interesting strategies in eight main TE application areas of epithelial, bone, uterine, vascular, nerve, cartilaginous, cardiac, and urinary tissue were included with the aim of learning about current approaches in TE. Different polymer-based medical devices approved for use in clinical trials and a wide variety of polymeric biomaterials are currently available as commercial products. However, there still are obstacles that limit the clinical translation of TE implants for use wide in humans, and much research work is still needed in the field of regenerative medicine.
KW - biomaterials
KW - regenerative medicine
KW - scaffolds
KW - stem cells
KW - tissue engineering
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U2 - 10.3390/bioengineering10020218
DO - 10.3390/bioengineering10020218
M3 - Review article
AN - SCOPUS:85149062164
SN - 2306-5354
VL - 10
JO - Bioengineering
JF - Bioengineering
IS - 2
M1 - 218
ER -