TY - JOUR
T1 - Polycyclic N‐hetero compounds. XXXVII. A convenient synthesis and evaluation of anti‐platelet aggregation activity of 1,2,4,5‐tetrahydro[1]‐ benzothiepino[4,5‐e]imidazo[1,2‐c]pyrimidine and its related compounds
AU - Nagamatsu, Tomohisa
AU - Kinoshita, Keiichi
AU - Sasaki, Kenji
AU - Nakayama, Taiji
AU - Hirota, Takashi
PY - 1991/1/1
Y1 - 1991/1/1
N2 - A simple and highly efficient methodology for the synthesis of 1,2,4,5‐tetrahydro[1]benzothiepino[4,5‐e]‐imidazo[1,2‐c]pyrimidine (XI) having a novel ring system via 4‐substituted 5,6‐dihydro[1]benzothiepino‐[5,4‐d]pyrimidines VII‐X is described. The anti‐platelet aggregation activity for it and its related compounds against collagen‐induced aggregation of rabbit blood platelets in vitro was found.
AB - A simple and highly efficient methodology for the synthesis of 1,2,4,5‐tetrahydro[1]benzothiepino[4,5‐e]‐imidazo[1,2‐c]pyrimidine (XI) having a novel ring system via 4‐substituted 5,6‐dihydro[1]benzothiepino‐[5,4‐d]pyrimidines VII‐X is described. The anti‐platelet aggregation activity for it and its related compounds against collagen‐induced aggregation of rabbit blood platelets in vitro was found.
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U2 - 10.1002/jhet.5570280260
DO - 10.1002/jhet.5570280260
M3 - Article
AN - SCOPUS:0025891592
VL - 28
SP - 513
EP - 515
JO - Journal of Heterocyclic Chemistry
JF - Journal of Heterocyclic Chemistry
SN - 0022-152X
IS - 2
ER -