Polycyclic N‐hetero compounds. XXXVII. A convenient synthesis and evaluation of anti‐platelet aggregation activity of 1,2,4,5‐tetrahydro[1]‐ benzothiepino[4,5‐e]imidazo[1,2‐c]pyrimidine and its related compounds

Tomohisa Nagamatsu; Keiichi Kinoshita; Kenji Sasaki; Taiji Nakayama; Takashi Hirota

doi:10.1002/jhet.5570280260

Polycyclic N‐hetero compounds. XXXVII. A convenient synthesis and evaluation of anti‐platelet aggregation activity of 1,2,4,5‐tetrahydro[1]‐ benzothiepino[4,5‐e]imidazo[1,2‐c]pyrimidine and its related compounds

Tomohisa Nagamatsu, Keiichi Kinoshita, Kenji Sasaki, Taiji Nakayama, Takashi Hirota

Institute for Education and Student Services

Research output: Contribution to journal › Article

14 Citations (Scopus)

Abstract

A simple and highly efficient methodology for the synthesis of 1,2,4,5‐tetrahydro[1]benzothiepino[4,5‐e]‐imidazo[1,2‐c]pyrimidine (XI) having a novel ring system via 4‐substituted 5,6‐dihydro[1]benzothiepino‐[5,4‐d]pyrimidines VII‐X is described. The anti‐platelet aggregation activity for it and its related compounds against collagen‐induced aggregation of rabbit blood platelets in vitro was found.

Original language	English
Pages (from-to)	513-515
Number of pages	3
Journal	Journal of Heterocyclic Chemistry
Volume	28
Issue number	2
DOIs	https://doi.org/10.1002/jhet.5570280260
Publication status	Published - Jan 1 1991

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ASJC Scopus subject areas

Organic Chemistry

Cite this

Nagamatsu, T., Kinoshita, K., Sasaki, K., Nakayama, T., & Hirota, T. (1991). Polycyclic N‐hetero compounds. XXXVII. A convenient synthesis and evaluation of anti‐platelet aggregation activity of 1,2,4,5‐tetrahydro[1]‐ benzothiepino[4,5‐e]imidazo[1,2‐c]pyrimidine and its related compounds. Journal of Heterocyclic Chemistry, 28(2), 513-515. https://doi.org/10.1002/jhet.5570280260

Polycyclic N‐hetero compounds. XXXVII. A convenient synthesis and evaluation of anti‐platelet aggregation activity of 1,2,4,5‐tetrahydro[1]‐ benzothiepino[4,5‐e]imidazo[1,2‐c]pyrimidine and its related compounds. / Nagamatsu, Tomohisa; Kinoshita, Keiichi; Sasaki, Kenji; Nakayama, Taiji; Hirota, Takashi.

In: Journal of Heterocyclic Chemistry, Vol. 28, No. 2, 01.01.1991, p. 513-515.

Research output: Contribution to journal › Article

Nagamatsu, T, Kinoshita, K, Sasaki, K, Nakayama, T & Hirota, T 1991, 'Polycyclic N‐hetero compounds. XXXVII. A convenient synthesis and evaluation of anti‐platelet aggregation activity of 1,2,4,5‐tetrahydro[1]‐ benzothiepino[4,5‐e]imidazo[1,2‐c]pyrimidine and its related compounds', Journal of Heterocyclic Chemistry, vol. 28, no. 2, pp. 513-515. https://doi.org/10.1002/jhet.5570280260

Nagamatsu T, Kinoshita K, Sasaki K, Nakayama T, Hirota T. Polycyclic N‐hetero compounds. XXXVII. A convenient synthesis and evaluation of anti‐platelet aggregation activity of 1,2,4,5‐tetrahydro[1]‐ benzothiepino[4,5‐e]imidazo[1,2‐c]pyrimidine and its related compounds. Journal of Heterocyclic Chemistry. 1991 Jan 1;28(2):513-515. https://doi.org/10.1002/jhet.5570280260

Nagamatsu, Tomohisa ; Kinoshita, Keiichi ; Sasaki, Kenji ; Nakayama, Taiji ; Hirota, Takashi. / Polycyclic N‐hetero compounds. XXXVII. A convenient synthesis and evaluation of anti‐platelet aggregation activity of 1,2,4,5‐tetrahydro[1]‐ benzothiepino[4,5‐e]imidazo[1,2‐c]pyrimidine and its related compounds. In: Journal of Heterocyclic Chemistry. 1991 ; Vol. 28, No. 2. pp. 513-515.

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