Polycyclic N‐hetero compounds. XXIX. Synthesis and antidepressive evaluation of 15‐thia‐11,13‐diazasteroidal analogues and their precursors

Takashi Hirota, Rieko Hamazaki, Takako Ohdoi, Kenji Sasaki, Tetsuto Namba

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    Abstract

    Syntheses of novel 15‐thia‐11,13‐diazasteroidal skeleton IV and its D‐homo analogues are described. Meso‐ionic derivatives of IV were also synthesized. Antidepressive activities of these compounds and their precursors were screened. D‐Dihomothiadiazasteroid IX and 3,4,5,6‐tetrahydrobenzo[h]quinazoline‐4‐thione (V) exhibited antireserpine action.

    Original languageEnglish
    Pages (from-to)341-344
    Number of pages4
    JournalJournal of Heterocyclic Chemistry
    Volume24
    Issue number2
    DOIs
    Publication statusPublished - Jan 1 1987

    ASJC Scopus subject areas

    • Organic Chemistry

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