Polycyclic N-heterocyclic compounds. Part 86: Synthesis and evaluation of antiplatelet aggregation activity of 2,4-disubstituted 9-chloro-5,6-dihydropyrimido[5,4-d]benzazepine and related compounds

Kensuke Okuda, Shigeki Takarada, Takashi Hirota, Kenji Sasaki

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2 Citations (Scopus)

Abstract

Libraries of tricyclic 2-substituted 4-alkylamino-9-chloro-5,6-dihydropyrimido[5,4-d]benzazepines and tetracyclic 12-substituted 8-chloro-1,2,5,6-tetrahydro-4H-imidazo[1',2':1,6]pyrimido[5,4-d]benzazepines were synthesized as part of our research to develop new effective antiplatelet drugs. Several alkyl and aryl groups were used as substituents at the 2-position. Evaluation of the effects of the newly synthesized compounds on collagen-induced platelet aggregation revealed several promising antiplatelet candidates with potencies superior to aspirin.

Original languageEnglish
Pages (from-to)780-792
Number of pages13
JournalJournal of Heterocyclic Chemistry
Volume52
Issue number3
DOIs
Publication statusPublished - May 1 2015

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Benzazepines
Heterocyclic Compounds
Agglomeration
Platelet Aggregation Inhibitors
Platelets
Aspirin
Collagen

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

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abstract = "Libraries of tricyclic 2-substituted 4-alkylamino-9-chloro-5,6-dihydropyrimido[5,4-d]benzazepines and tetracyclic 12-substituted 8-chloro-1,2,5,6-tetrahydro-4H-imidazo[1',2':1,6]pyrimido[5,4-d]benzazepines were synthesized as part of our research to develop new effective antiplatelet drugs. Several alkyl and aryl groups were used as substituents at the 2-position. Evaluation of the effects of the newly synthesized compounds on collagen-induced platelet aggregation revealed several promising antiplatelet candidates with potencies superior to aspirin.",
author = "Kensuke Okuda and Shigeki Takarada and Takashi Hirota and Kenji Sasaki",
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T1 - Polycyclic N-heterocyclic compounds. Part 86

T2 - Synthesis and evaluation of antiplatelet aggregation activity of 2,4-disubstituted 9-chloro-5,6-dihydropyrimido[5,4-d]benzazepine and related compounds

AU - Okuda, Kensuke

AU - Takarada, Shigeki

AU - Hirota, Takashi

AU - Sasaki, Kenji

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AB - Libraries of tricyclic 2-substituted 4-alkylamino-9-chloro-5,6-dihydropyrimido[5,4-d]benzazepines and tetracyclic 12-substituted 8-chloro-1,2,5,6-tetrahydro-4H-imidazo[1',2':1,6]pyrimido[5,4-d]benzazepines were synthesized as part of our research to develop new effective antiplatelet drugs. Several alkyl and aryl groups were used as substituents at the 2-position. Evaluation of the effects of the newly synthesized compounds on collagen-induced platelet aggregation revealed several promising antiplatelet candidates with potencies superior to aspirin.

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