Polycyclic N-heterocyclic compounds. Part 85: Synthesis and evaluation of antiplatelet aggregation activity of 2,4-disubstituted 5,6-dihydro[1]benzazepino[5,4-d]pyrimidine and related compounds

Kensuke Okuda, Ying Xue Zhang, Takashi Hirota, Kenji Sasaki

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Abstract

We have synthesized a large number of tricyclic 2-substituted 4-alkylamino-5,6-dihydro[1]benzazepino[5,4-d]pyrimidines as part of our research to develop new effective antiplatelet drugs. A variety of alkyl and aryl groups were used as substituents at the 2-position. Evaluation of the effects of the newly synthesized compounds on collagen-induced platelet aggregation revealed several promising antiplatelet candidates with potencies superior to aspirin.

Original languageEnglish
Pages (from-to)888-895
Number of pages8
JournalJournal of Heterocyclic Chemistry
Volume52
Issue number3
DOIs
Publication statusPublished - May 1 2015

ASJC Scopus subject areas

  • Organic Chemistry

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