Reaction of 3-(3-cyanopropylthio)benzothiophene-2-carbonitrile with tert-BuONa gave 5-amino-1,2-dihydrobenzothieno[3,2-d]thieno[2,3-b]pyridine and 5-amino-2,3-dihydrobenzothieno[3,2-b]thiepin-4-carbonitrile. The latter compound served as a convenient scaffold for the synthesis of the new heterocycles, benzothieno[3′,2′:2,3]thiepino[4,5-d]pyrimidines. All of our new tetracyclic products were evaluated for in vitro inhibitory activity on the formation of pentosidine, which is one of representative advanced glycation end products.
ASJC Scopus subject areas
- Organic Chemistry