Polycyclic N-heterocyclic compounds. Part 80: Synthesis and evaluation of effects on in vitro pentosidine formation of 5,6-dihydro[1]benzothieno[3′, 2′:2,3]thiepino[4,5-d]pyrimidine and related compounds

Kensuke Okuda, Yutaka Itsuji, Takashi Hirota, Kenji Sasaki

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    Reaction of 3-(3-cyanopropylthio)[1]benzothiophene-2-carbonitrile with tert-BuONa gave 5-amino-1,2-dihydro[1]benzothieno[3,2-d]thieno[2,3-b]pyridine and 5-amino-2,3-dihydro[1]benzothieno[3,2-b]thiepin-4-carbonitrile. The latter compound served as a convenient scaffold for the synthesis of the new heterocycles, [1]benzothieno[3′,2′:2,3]thiepino[4,5-d]pyrimidines. All of our new tetracyclic products were evaluated for in vitro inhibitory activity on the formation of pentosidine, which is one of representative advanced glycation end products.

    Original languageEnglish
    Pages (from-to)891-898
    Number of pages8
    JournalJournal of Heterocyclic Chemistry
    Volume51
    Issue number4
    DOIs
    Publication statusPublished - Jul 2014

    ASJC Scopus subject areas

    • Organic Chemistry

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