Polycyclic N-heterocyclic compounds. Part 79

Synthesis of 2,4-disubstituted 6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidines as potential antiplatelet aggregators

Kensuke Okuda, Takashi Hirota, Kenji Sasaki

Research output: Contribution to journalArticle

Abstract

Libraries of tricyclic 2-substituted 4-alkylamino-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidines were synthesized as part of our research to develop new effective antiplatelet drugs. Several alkyl and aryl groups were used as substituents at the 2-position. Evaluation of the effects of the newly synthesized compounds on collagen-induced platelet aggregation revealed several promising antiplatelet candidates with potencies superior to aspirin.

Original languageEnglish
Pages (from-to)1607-1614
Number of pages8
JournalJournal of Heterocyclic Chemistry
Volume51
Issue number6
DOIs
Publication statusPublished - Nov 24 2014

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Heterocyclic Compounds
Pyrimidines
Platelet Aggregation Inhibitors
Platelets
Aspirin
Collagen
Agglomeration

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

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title = "Polycyclic N-heterocyclic compounds. Part 79: Synthesis of 2,4-disubstituted 6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidines as potential antiplatelet aggregators",
abstract = "Libraries of tricyclic 2-substituted 4-alkylamino-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidines were synthesized as part of our research to develop new effective antiplatelet drugs. Several alkyl and aryl groups were used as substituents at the 2-position. Evaluation of the effects of the newly synthesized compounds on collagen-induced platelet aggregation revealed several promising antiplatelet candidates with potencies superior to aspirin.",
author = "Kensuke Okuda and Takashi Hirota and Kenji Sasaki",
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T2 - Synthesis of 2,4-disubstituted 6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidines as potential antiplatelet aggregators

AU - Okuda, Kensuke

AU - Hirota, Takashi

AU - Sasaki, Kenji

PY - 2014/11/24

Y1 - 2014/11/24

N2 - Libraries of tricyclic 2-substituted 4-alkylamino-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidines were synthesized as part of our research to develop new effective antiplatelet drugs. Several alkyl and aryl groups were used as substituents at the 2-position. Evaluation of the effects of the newly synthesized compounds on collagen-induced platelet aggregation revealed several promising antiplatelet candidates with potencies superior to aspirin.

AB - Libraries of tricyclic 2-substituted 4-alkylamino-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidines were synthesized as part of our research to develop new effective antiplatelet drugs. Several alkyl and aryl groups were used as substituents at the 2-position. Evaluation of the effects of the newly synthesized compounds on collagen-induced platelet aggregation revealed several promising antiplatelet candidates with potencies superior to aspirin.

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