Polycyclic N-heterocyclic compounds. Part 78: Synthesis of N-[2-([1,2,4]oxadiazol-5-yl)cyclohepten-1-yl]formamide oximes and their evaluation as inhibitors of platelet aggregation

Kensuke Okuda, Ying Xue Zhang, Takashi Hirota, Kenji Sasaki

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)

    Abstract

    N-[2-([1,2,4]Oxadiazol-5-yl)cyclohepten-1-yl]formamide oximes were synthesized by fusion of (6,7,8,9-tetrahydro-5H-cyclohepta[1,2-d]pyrimidin-4-yl) amidines with hydroxylamine hydrochloride through a subsequent rearrangement reaction. Effects of the products as well as the structurally related N-[4-([1,2,4]oxadiazol-5-yl)-2,3-dihydro[1]benzoxepin-5-yl]formamide oximes and N-[4-([1,2,4]oxadiazol-5-yl)-2,3-dihydro[1]benzothiepin-5-yl]formamide oximes on platelet aggregation were evaluated.

    Original languageEnglish
    Pages (from-to)518-522
    Number of pages5
    JournalJournal of Heterocyclic Chemistry
    Volume51
    Issue number2
    DOIs
    Publication statusPublished - Mar 2014

    ASJC Scopus subject areas

    • Organic Chemistry

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