Polycyclic N-heterocyclic compounds. Part 78: Synthesis of N-[2-([1,2,4]oxadiazol-5-yl)cyclohepten-1-yl]formamide oximes and their evaluation as inhibitors of platelet aggregation

Kensuke Okuda, Ying Xue Zhang, Takashi Hirota, Kenji Sasaki

Research output: Contribution to journalArticle

Abstract

N-[2-([1,2,4]Oxadiazol-5-yl)cyclohepten-1-yl]formamide oximes were synthesized by fusion of (6,7,8,9-tetrahydro-5H-cyclohepta[1,2-d]pyrimidin-4-yl) amidines with hydroxylamine hydrochloride through a subsequent rearrangement reaction. Effects of the products as well as the structurally related N-[4-([1,2,4]oxadiazol-5-yl)-2,3-dihydro[1]benzoxepin-5-yl]formamide oximes and N-[4-([1,2,4]oxadiazol-5-yl)-2,3-dihydro[1]benzothiepin-5-yl]formamide oximes on platelet aggregation were evaluated.

Original languageEnglish
Pages (from-to)518-522
Number of pages5
JournalJournal of Heterocyclic Chemistry
Volume51
Issue number2
DOIs
Publication statusPublished - Mar 2014

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ASJC Scopus subject areas

  • Organic Chemistry

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