TY - JOUR
T1 - Polycyclic N-heterocyclic compounds. Part 78
T2 - Synthesis of N-[2-([1,2,4]oxadiazol-5-yl)cyclohepten-1-yl]formamide oximes and their evaluation as inhibitors of platelet aggregation
AU - Okuda, Kensuke
AU - Zhang, Ying Xue
AU - Hirota, Takashi
AU - Sasaki, Kenji
PY - 2014/3
Y1 - 2014/3
N2 - N-[2-([1,2,4]Oxadiazol-5-yl)cyclohepten-1-yl]formamide oximes were synthesized by fusion of (6,7,8,9-tetrahydro-5H-cyclohepta[1,2-d]pyrimidin-4-yl) amidines with hydroxylamine hydrochloride through a subsequent rearrangement reaction. Effects of the products as well as the structurally related N-[4-([1,2,4]oxadiazol-5-yl)-2,3-dihydro[1]benzoxepin-5-yl]formamide oximes and N-[4-([1,2,4]oxadiazol-5-yl)-2,3-dihydro[1]benzothiepin-5-yl]formamide oximes on platelet aggregation were evaluated.
AB - N-[2-([1,2,4]Oxadiazol-5-yl)cyclohepten-1-yl]formamide oximes were synthesized by fusion of (6,7,8,9-tetrahydro-5H-cyclohepta[1,2-d]pyrimidin-4-yl) amidines with hydroxylamine hydrochloride through a subsequent rearrangement reaction. Effects of the products as well as the structurally related N-[4-([1,2,4]oxadiazol-5-yl)-2,3-dihydro[1]benzoxepin-5-yl]formamide oximes and N-[4-([1,2,4]oxadiazol-5-yl)-2,3-dihydro[1]benzothiepin-5-yl]formamide oximes on platelet aggregation were evaluated.
UR - http://www.scopus.com/inward/record.url?scp=84897466361&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84897466361&partnerID=8YFLogxK
U2 - 10.1002/jhet.1628
DO - 10.1002/jhet.1628
M3 - Article
AN - SCOPUS:84897466361
VL - 51
SP - 518
EP - 522
JO - Journal of Heterocyclic Chemistry
JF - Journal of Heterocyclic Chemistry
SN - 0022-152X
IS - 2
ER -