Several 5-substituted 1,2-dihydrofuro[3,2-f][1,7]naphthyridines were synthesized as part of our research to develop new effective bronchodilators. Amines, sulfanyls, and alcohols were used as substituents at the fifth position. Tetracyclic compounds were also obtained. Evaluation of the effects of the newly synthesized compounds on carbamoylcholine chloride-induced contractions of trachea revealed one promising bronchodilator candidate with potency comparable to that of 3-isobutyl-1-methylxanthine.
ASJC Scopus subject areas
- Organic Chemistry