Polycyclic N-heterocyclic compounds, part 71: Synthesis and bronchodilator evaluation of 5-substituted 1,2-dihydrofuro[3,2-f][1,7]naphthyridines and related compounds

Kensuke Okuda, Tetsuo Matsushita, Takashi Hirota, Kenji Sasaki

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Abstract

Several 5-substituted 1,2-dihydrofuro[3,2-f][1,7]naphthyridines were synthesized as part of our research to develop new effective bronchodilators. Amines, sulfanyls, and alcohols were used as substituents at the fifth position. Tetracyclic compounds were also obtained. Evaluation of the effects of the newly synthesized compounds on carbamoylcholine chloride-induced contractions of trachea revealed one promising bronchodilator candidate with potency comparable to that of 3-isobutyl-1-methylxanthine.

Original languageEnglish
Pages (from-to)742-747
Number of pages6
JournalJournal of Heterocyclic Chemistry
Volume49
Issue number4
DOIs
Publication statusPublished - Jul 1 2012

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ASJC Scopus subject areas

  • Organic Chemistry

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