Polycyclic N-heterocyclic compounds, part 69: Synthesis of 5-amino-1,2-dihydro[1]benzofuro[3,2-d]furo[2,3-b]pyridines and their transformations to related compounds

Kensuke Okuda, Jun Ichi Takano, Takashi Hirota, Kenji Sasaki

Research output: Contribution to journal › Article

9 Citations (Scopus)

Abstract

Reaction of 3-(3-cyanopropoxy)[1]benzofuran-2-carbonitriles with potassium tert-butoxide gave 5-amino-1,2-dihydro[1]benzofuro[3,2-d]furo[2,3-b]pyridines and 5-amino-2,3-dihydro[1]benzofuro[3,2-b]oxepin-4-carbonitriles as new ring systems. Reactions of the 5-chloro derivative, obtained from 5-amino-1,2-dihydro[1]benzofuro[3,2-d]furo[2,3-b]pyridine, produced a dihydrofuran ring-opened compound and 5-substituted compounds.

Original languageEnglish
Pages (from-to)281-287
Number of pages7
JournalJournal of Heterocyclic Chemistry
Volume49
Issue number2
DOIs
Publication statusPublished - Mar 2012

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Heterocyclic Compounds
Oxepins
Derivatives
furo(3,2-b)pyridine
potassium tert-butoxide
1-benzofuran

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Polycyclic N-heterocyclic compounds, part 69 : Synthesis of 5-amino-1,2-dihydro[1]benzofuro[3,2-d]furo[2,3-b]pyridines and their transformations to related compounds. / Okuda, Kensuke; Takano, Jun Ichi; Hirota, Takashi; Sasaki, Kenji.

In: Journal of Heterocyclic Chemistry, Vol. 49, No. 2, 03.2012, p. 281-287.

Research output: Contribution to journal › Article

Okuda, K, Takano, JI, Hirota, T & Sasaki, K 2012, 'Polycyclic N-heterocyclic compounds, part 69: Synthesis of 5-amino-1,2-dihydro[1]benzofuro[3,2-d]furo[2,3-b]pyridines and their transformations to related compounds', Journal of Heterocyclic Chemistry, vol. 49, no. 2, pp. 281-287. https://doi.org/10.1002/jhet.772
Okuda K, Takano JI, Hirota T, Sasaki K. Polycyclic N-heterocyclic compounds, part 69: Synthesis of 5-amino-1,2-dihydro[1]benzofuro[3,2-d]furo[2,3-b]pyridines and their transformations to related compounds. Journal of Heterocyclic Chemistry. 2012 Mar;49(2):281-287. https://doi.org/10.1002/jhet.772
Okuda, Kensuke ; Takano, Jun Ichi ; Hirota, Takashi ; Sasaki, Kenji. / Polycyclic N-heterocyclic compounds, part 69 : Synthesis of 5-amino-1,2-dihydro[1]benzofuro[3,2-d]furo[2,3-b]pyridines and their transformations to related compounds. In: Journal of Heterocyclic Chemistry. 2012 ; Vol. 49, No. 2. pp. 281-287.
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