TY - JOUR
T1 - Polycyclic N-heterocyclic compounds. Part 66
T2 - Synthesis of N-[2-([1,2,4]oxadiazol-5-yl)cyclopenten-1-yl]formamide oximes and their evaluation as inhibitors of platelet aggregation
AU - Okuda, Kensuke
AU - Zhang, Ying Xue
AU - Ohtomo, Hiromi
AU - Hirota, Takashi
AU - Sasaki, Kenji
PY - 2011/5/1
Y1 - 2011/5/1
N2 - N-[2-([1,2,4]Oxadiazol-5-yl)cyclopenten-1-yl]formamide oximes were synthesized by fusion of (6,7-dihydro-5H-cyclopenta[1,2-d]pyrimidin-4-yl) amidines and/or their amide oximes with hydroxylamine hydrochloride through a subsequent rearrangement reaction. Assay of the products for anti-platelet aggregation activity revealed that certain of them showed promising inhibitory effect on arachidonic acid-induced platelet aggregation.
AB - N-[2-([1,2,4]Oxadiazol-5-yl)cyclopenten-1-yl]formamide oximes were synthesized by fusion of (6,7-dihydro-5H-cyclopenta[1,2-d]pyrimidin-4-yl) amidines and/or their amide oximes with hydroxylamine hydrochloride through a subsequent rearrangement reaction. Assay of the products for anti-platelet aggregation activity revealed that certain of them showed promising inhibitory effect on arachidonic acid-induced platelet aggregation.
UR - http://www.scopus.com/inward/record.url?scp=79957533807&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79957533807&partnerID=8YFLogxK
U2 - 10.1002/jhet.564
DO - 10.1002/jhet.564
M3 - Article
AN - SCOPUS:79957533807
SN - 0022-152X
VL - 48
SP - 715
EP - 719
JO - Journal of Heterocyclic Chemistry
JF - Journal of Heterocyclic Chemistry
IS - 3
ER -