Polycyclic N-heterocyclic compounds. Part 66: Synthesis of N-[2-([1,2,4]oxadiazol-5-yl)cyclopenten-1-yl]formamide oximes and their evaluation as inhibitors of platelet aggregation

Kensuke Okuda, Ying Xue Zhang, Hiromi Ohtomo, Takashi Hirota, Kenji Sasaki

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N-[2-([1,2,4]Oxadiazol-5-yl)cyclopenten-1-yl]formamide oximes were synthesized by fusion of (6,7-dihydro-5H-cyclopenta[1,2-d]pyrimidin-4-yl) amidines and/or their amide oximes with hydroxylamine hydrochloride through a subsequent rearrangement reaction. Assay of the products for anti-platelet aggregation activity revealed that certain of them showed promising inhibitory effect on arachidonic acid-induced platelet aggregation.

Original languageEnglish
Pages (from-to)715-719
Number of pages5
JournalJournal of Heterocyclic Chemistry
Issue number3
Publication statusPublished - May 2011


ASJC Scopus subject areas

  • Organic Chemistry

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