Abstract
Reaction of some fused tricyclic 3-(2-bromoethyl)pyrimidin-4(3H)-ones with primary alkyl amines gave abnormal fused 3-alkyl-4-alkyliminopyrimidines via a Dimroth-type rearrangement, as well as normal substituted 3-(2-alkylaminoethyl) derivatives in methanol. This abnormal rearrangement reaction depended on reaction solvent.
| Original language | English |
|---|---|
| Pages (from-to) | 755-758 |
| Number of pages | 4 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 57 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 1 2009 |
Keywords
- 3-alkyl-4-alkyliminopyrimidine
- Dimroth rearrangement
- Heterocycle
- Pyrimidin-4(3H)-one
- Tandem reaction
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery
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Cite this
Okuda, K., Ohtomo, H., Tanaka, F., Hirota, T., & Sasaki, K. (2009). Polycyclic N-heterocyclic compounds. Part 59: Rearrangement reactions of fused tricyclic 3-(2-bromoethyl)pyrimidin-4(3H)-ones with primary amines via a Dimroth-type rearrangement. Chemical and Pharmaceutical Bulletin, 57(7), 755-758. https://doi.org/10.1248/cpb.57.755