Polycyclic N-heterocyclic compounds. Part 58: Rearrangement reactions of fused 3-(2-bromoethyl)pyrimidin-4(3H)-ones with primary amines and antidepressive evaluation of the products

Hiromi Ohtomo, Tsuyoshi Tagata, Kenji Sasaki, Takashi Hirota, Kensuke Okuda

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Reaction of fused 3-(2-bromoethyl)pyrimidin-4(3H)-ones with primary alkylamines gave abnormal fused 3-alkyl-4-alkyliminopyrimidines via a new rearrangement, as well as normal substituted 3-(2-alkylaminoethyl) derivatives. Antidepressive evaluation of these compounds was performed by antireserpine action and one compound exhibited the positive activity comparable to imipramine.

Original languageEnglish
Pages (from-to)12541-12546
Number of pages6
JournalTetrahedron
Volume63
Issue number51
DOIs
Publication statusPublished - Dec 17 2007

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Heterocyclic Compounds
Imipramine
Amines
Derivatives

Keywords

  • 3-Alkyl-4-alkyliminopyrimidine
  • Antidepressant
  • Pyrimidin-4(3H)-one
  • Rearrangement

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Polycyclic N-heterocyclic compounds. Part 58 : Rearrangement reactions of fused 3-(2-bromoethyl)pyrimidin-4(3H)-ones with primary amines and antidepressive evaluation of the products. / Ohtomo, Hiromi; Tagata, Tsuyoshi; Sasaki, Kenji; Hirota, Takashi; Okuda, Kensuke.

In: Tetrahedron, Vol. 63, No. 51, 17.12.2007, p. 12541-12546.

Research output: Contribution to journalArticle

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