Polycyclic N-heterocyclic compounds. Part 58: Rearrangement reactions of fused 3-(2-bromoethyl)pyrimidin-4(3H)-ones with primary amines and antidepressive evaluation of the products

Hiromi Ohtomo, Tsuyoshi Tagata, Kenji Sasaki, Takashi Hirota, Kensuke Okuda

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)

    Abstract

    Reaction of fused 3-(2-bromoethyl)pyrimidin-4(3H)-ones with primary alkylamines gave abnormal fused 3-alkyl-4-alkyliminopyrimidines via a new rearrangement, as well as normal substituted 3-(2-alkylaminoethyl) derivatives. Antidepressive evaluation of these compounds was performed by antireserpine action and one compound exhibited the positive activity comparable to imipramine.

    Original languageEnglish
    Pages (from-to)12541-12546
    Number of pages6
    JournalTetrahedron
    Volume63
    Issue number51
    DOIs
    Publication statusPublished - Dec 17 2007

    Keywords

    • 3-Alkyl-4-alkyliminopyrimidine
    • Antidepressant
    • Pyrimidin-4(3H)-one
    • Rearrangement

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

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