Polycyclic N-heterocyclic compounds. Part 52. One-step syntheses of imidazo[1,5-a]pyridines, imidazo[1,5-a]quinolines and imidazo[5,1-a]isoquinolines by Vilsmeier reactions of pyridine-2-carbonitriles, quinoline-2-carbonitriles and isoquinoline-1-carbonitriles

Kenji Sasaki, Akifumi Tsurumori, Takashi Hirota

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

The versatile, one-step synthesis of imidazo[1,5-a]pyridines by the reaction of pyridine-2-carbonitriles with DMF under Vilsmeier conditions is described. This reaction was applied to the syntheses of imidazo[1,5-a]quinolines from quinoline-2-carbonitriles, and of imidazo[5,1-a]isoquinolines from isoquinoline-1-carbonitriles.

Original languageEnglish
Pages (from-to)3851-3856
Number of pages6
JournalJournal of the Chemical Society - Perkin Transactions 1
Issue number22
DOIs
Publication statusPublished - Nov 21 1998

ASJC Scopus subject areas

  • Chemistry(all)

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