Polycyclic N-heterocyclic compounds 83: Synthesis of 2,4-disubstituted 5,6-dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5-d]pyrimidines and 2,4,5-Trisubstituted 5,6-Dihydro[1]benzofuro[2′,3′:5,6]pyrano[4,3-d] pyrimidines from 4-Chloro-5,6-dihydro[1]benzofuro[3′,2′:2,3] oxepino[4,5-d]pyrimidines

Kensuke Okuda, Jun Ichi Takano, Takashi Hirota, Kenji Sasaki

Research output: Contribution to journalArticle

Abstract

Treatment of 2-substituted 4-chloro-5,6-dihydro[1]benzofuro[3′, 2′:2,3]oxepino[4,5-d]pyrimidines with simple alcohols and thiols as nucleophile afforded 2-substituted 4-alkoxy (or sulfanyl) derivatives. In the case of alkoxide nucleophiles, rearranged reaction products were also obtained. X-ray crystallography was used to support the structure assignment of the rearranged product.

Original languageEnglish
Pages (from-to)788-793
Number of pages6
JournalJournal of Heterocyclic Chemistry
Volume51
Issue number3
DOIs
Publication statusPublished - May 2014

ASJC Scopus subject areas

  • Organic Chemistry

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