Treatment of 2-substituted 4-chloro-5,6-dihydrobenzofuro[3′, 2′:2,3]oxepino[4,5-d]pyrimidines with simple alcohols and thiols as nucleophile afforded 2-substituted 4-alkoxy (or sulfanyl) derivatives. In the case of alkoxide nucleophiles, rearranged reaction products were also obtained. X-ray crystallography was used to support the structure assignment of the rearranged product.
ASJC Scopus subject areas
- Organic Chemistry