Polycyclic N-heterocyclic compounds 73: Synthesis and evaluation of 5-substituted 1,2-dihydrofuro[2,3-c ]isoquinolines as inducers of lipoprotein lipase mRNA expression

Kensuke Okuda, Masahiko Yoshida, Takashi Hirota, Kenji Sasaki

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3 Citations (Scopus)

Abstract

Several 5-substituted 1,2-dihydro[2,3-c]isoquinoline derivatives were synthesized as part of our research to develop new diabetes drugs. Amines and sulfanyls were used as substituents at the 5th-position. Evaluation of the effects of the newly synthesized compounds on lipoprotein lipase mRNA expression in 3T3-L1 preadipocytes revealed one promising candidate with potency comparable to that of troglitazone.

Original languageEnglish
JournalJournal of Heterocyclic Chemistry
Volume50
Issue numberSUPPL.1
DOIs
Publication statusPublished - Feb 2013

Fingerprint

troglitazone
Isoquinolines
Heterocyclic Compounds
Lipoprotein Lipase
Medical problems
Amines
Derivatives
Messenger RNA
Pharmaceutical Preparations
isoquinoline

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

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AU - Okuda, Kensuke

AU - Yoshida, Masahiko

AU - Hirota, Takashi

AU - Sasaki, Kenji

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AB - Several 5-substituted 1,2-dihydro[2,3-c]isoquinoline derivatives were synthesized as part of our research to develop new diabetes drugs. Amines and sulfanyls were used as substituents at the 5th-position. Evaluation of the effects of the newly synthesized compounds on lipoprotein lipase mRNA expression in 3T3-L1 preadipocytes revealed one promising candidate with potency comparable to that of troglitazone.

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