Abstract
Several 5-substituted 1,2-dihydro[2,3-c]isoquinoline derivatives were synthesized as part of our research to develop new diabetes drugs. Amines and sulfanyls were used as substituents at the 5th-position. Evaluation of the effects of the newly synthesized compounds on lipoprotein lipase mRNA expression in 3T3-L1 preadipocytes revealed one promising candidate with potency comparable to that of troglitazone.
| Original language | English |
|---|---|
| Pages (from-to) | E9-E11 |
| Journal | Journal of Heterocyclic Chemistry |
| Volume | 50 |
| Issue number | SUPPL.1 |
| DOIs | |
| Publication status | Published - Feb 1 2013 |
ASJC Scopus subject areas
- Organic Chemistry
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Okuda, K., Yoshida, M., Hirota, T., & Sasaki, K. (2013). Polycyclic N-heterocyclic compounds 73: Synthesis and evaluation of 5-substituted 1,2-dihydrofuro[2,3-c ]isoquinolines as inducers of lipoprotein lipase mRNA expression. Journal of Heterocyclic Chemistry, 50(SUPPL.1), E9-E11. https://doi.org/10.1002/jhet.1016