Abstract
Several 5-substituted 1,2-dihydro[2,3-c]isoquinoline derivatives were synthesized as part of our research to develop new diabetes drugs. Amines and sulfanyls were used as substituents at the 5th-position. Evaluation of the effects of the newly synthesized compounds on lipoprotein lipase mRNA expression in 3T3-L1 preadipocytes revealed one promising candidate with potency comparable to that of troglitazone.
| Original language | English |
|---|---|
| Journal | Journal of Heterocyclic Chemistry |
| Volume | 50 |
| Issue number | SUPPL.1 |
| DOIs | |
| Publication status | Published - Feb 2013 |
Fingerprint
ASJC Scopus subject areas
- Organic Chemistry
Cite this
Polycyclic N-heterocyclic compounds 73 : Synthesis and evaluation of 5-substituted 1,2-dihydrofuro[2,3-c ]isoquinolines as inducers of lipoprotein lipase mRNA expression. / Okuda, Kensuke; Yoshida, Masahiko; Hirota, Takashi; Sasaki, Kenji.
In: Journal of Heterocyclic Chemistry, Vol. 50, No. SUPPL.1, 02.2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Polycyclic N-heterocyclic compounds 73
T2 - Synthesis and evaluation of 5-substituted 1,2-dihydrofuro[2,3-c ]isoquinolines as inducers of lipoprotein lipase mRNA expression
AU - Okuda, Kensuke
AU - Yoshida, Masahiko
AU - Hirota, Takashi
AU - Sasaki, Kenji
PY - 2013/2
Y1 - 2013/2
N2 - Several 5-substituted 1,2-dihydro[2,3-c]isoquinoline derivatives were synthesized as part of our research to develop new diabetes drugs. Amines and sulfanyls were used as substituents at the 5th-position. Evaluation of the effects of the newly synthesized compounds on lipoprotein lipase mRNA expression in 3T3-L1 preadipocytes revealed one promising candidate with potency comparable to that of troglitazone.
AB - Several 5-substituted 1,2-dihydro[2,3-c]isoquinoline derivatives were synthesized as part of our research to develop new diabetes drugs. Amines and sulfanyls were used as substituents at the 5th-position. Evaluation of the effects of the newly synthesized compounds on lipoprotein lipase mRNA expression in 3T3-L1 preadipocytes revealed one promising candidate with potency comparable to that of troglitazone.
UR - http://www.scopus.com/inward/record.url?scp=84876920851&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876920851&partnerID=8YFLogxK
U2 - 10.1002/jhet.1016
DO - 10.1002/jhet.1016
M3 - Article
AN - SCOPUS:84876920851
VL - 50
JO - Journal of Heterocyclic Chemistry
JF - Journal of Heterocyclic Chemistry
SN - 0022-152X
IS - SUPPL.1
ER -