Polycyclic N-heterocyclic compounds 73: Synthesis and evaluation of 5-substituted 1,2-dihydrofuro[2,3-c ]isoquinolines as inducers of lipoprotein lipase mRNA expression

Kensuke Okuda, Masahiko Yoshida, Takashi Hirota, Kenji Sasaki

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Several 5-substituted 1,2-dihydro[2,3-c]isoquinoline derivatives were synthesized as part of our research to develop new diabetes drugs. Amines and sulfanyls were used as substituents at the 5th-position. Evaluation of the effects of the newly synthesized compounds on lipoprotein lipase mRNA expression in 3T3-L1 preadipocytes revealed one promising candidate with potency comparable to that of troglitazone.

    Original languageEnglish
    Pages (from-to)E9-E11
    JournalJournal of Heterocyclic Chemistry
    Volume50
    Issue numberSUPPL.1
    DOIs
    Publication statusPublished - Feb 1 2013

    ASJC Scopus subject areas

    • Organic Chemistry

    Fingerprint

    Dive into the research topics of 'Polycyclic N-heterocyclic compounds 73: Synthesis and evaluation of 5-substituted 1,2-dihydrofuro[2,3-c ]isoquinolines as inducers of lipoprotein lipase mRNA expression'. Together they form a unique fingerprint.

    Cite this