TY - JOUR
T1 - Polycyclic N-heterocyclic compounds 73
T2 - Synthesis and evaluation of 5-substituted 1,2-dihydrofuro[2,3-c ]isoquinolines as inducers of lipoprotein lipase mRNA expression
AU - Okuda, Kensuke
AU - Yoshida, Masahiko
AU - Hirota, Takashi
AU - Sasaki, Kenji
PY - 2013/2/1
Y1 - 2013/2/1
N2 - Several 5-substituted 1,2-dihydro[2,3-c]isoquinoline derivatives were synthesized as part of our research to develop new diabetes drugs. Amines and sulfanyls were used as substituents at the 5th-position. Evaluation of the effects of the newly synthesized compounds on lipoprotein lipase mRNA expression in 3T3-L1 preadipocytes revealed one promising candidate with potency comparable to that of troglitazone.
AB - Several 5-substituted 1,2-dihydro[2,3-c]isoquinoline derivatives were synthesized as part of our research to develop new diabetes drugs. Amines and sulfanyls were used as substituents at the 5th-position. Evaluation of the effects of the newly synthesized compounds on lipoprotein lipase mRNA expression in 3T3-L1 preadipocytes revealed one promising candidate with potency comparable to that of troglitazone.
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U2 - 10.1002/jhet.1016
DO - 10.1002/jhet.1016
M3 - Article
AN - SCOPUS:84876920851
VL - 50
SP - E9-E11
JO - Journal of Heterocyclic Chemistry
JF - Journal of Heterocyclic Chemistry
SN - 0022-152X
IS - SUPPL.1
ER -
