Polycyclic N-heterocyclic compounds 73: Synthesis and evaluation of 5-substituted 1,2-dihydrofuro[2,3-c ]isoquinolines as inducers of lipoprotein lipase mRNA expression

Kensuke Okuda, Masahiko Yoshida, Takashi Hirota, Kenji Sasaki

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Several 5-substituted 1,2-dihydro[2,3-c]isoquinoline derivatives were synthesized as part of our research to develop new diabetes drugs. Amines and sulfanyls were used as substituents at the 5th-position. Evaluation of the effects of the newly synthesized compounds on lipoprotein lipase mRNA expression in 3T3-L1 preadipocytes revealed one promising candidate with potency comparable to that of troglitazone.

Original languageEnglish
Pages (from-to)E9-E11
JournalJournal of Heterocyclic Chemistry
Volume50
Issue numberSUPPL.1
DOIs
Publication statusPublished - Feb 1 2013

ASJC Scopus subject areas

  • Organic Chemistry

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