Polycyclic N-heterocyclic compounds. 57 Syntheses of fused furo(or thieno)[2,3-b]pyridine derivatives via smiles rearrangement and cyclization

Takashi Hirota, Kei Ichiroh Tomita, Kenji Sasaki, Kensuke Okuda, Masahiko Yoshida, Setsuo Kashino

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

An efficient methodology for the synthesis of thieno[2,3-c][2,7]-naphthyridine (6), thieno[2,3-c]isoquinoline (11), furo[2,3-c]isoquinoline (14), [1]benzothieno[3,2-d]thieno[2,3-b]pyridine (21), and [1]benzothieno[3,2-d]furo-[2,3-b]pyridine (26) skeletons from 4-[o-cyanoarylthio(or oxy)]butyronitriles with base via Smiles type rearrangement reaction followed by the cyclization is described.

Original languageEnglish
Pages (from-to)741-752
Number of pages12
JournalHeterocycles
Volume55
Issue number4
DOIs
Publication statusPublished - Apr 1 2001

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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